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首页> 外文期刊>Clinical drug investigation >Age-Related Differences in Non-Persistence with Statin Treatment in Patients after a Transient Ischaemic Attack
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Age-Related Differences in Non-Persistence with Statin Treatment in Patients after a Transient Ischaemic Attack

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AbstractBackground and ObjectiveNon-persistence with secondary preventive measures, including medications such as statins, adversely affects the prospects of successful outcomes. This study was aimed at evaluating non-persistence with statin therapy in cohorts of young and elderly patients after a transient ischaemic attack (TIA) and identifying patient-associated characteristics that influence the risk for non-persistence.MethodsThe study cohorts included 797 adult patients who were initiated on statin therapy following a TIA diagnosis between 1 January 2010 and 31 December 2010. Patients were followed up for 3 years and those with a treatment gap of at least a 6-month period were considered ‘non-persistent’. In order to identify any age-related differences, all analyses were conducted in the entire study cohort (n?=?797) as well as separately in the ‘younger’ (aged n?=?267) and the ‘older’ (aged ≥65 years,n?=?530) patients.ResultsNon-persistence was significantly more common in younger patients compared to older patients (67.8 vs. 49.1;p?ConclusionsOur results indicate that certain patients with TIA require special counselling to improve persistence with statin therapy. These include younger patients, especially females and those not on polypharmacy, and both younger and older patients without diabetes mellitus or hypercholesterolaemia.>

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  • 来源
    《Clinical drug investigation》 |2017年第11期|1047-1054|共8页
  • 作者

    Martin Wawruch; Dusan Zatko; Gejza WimmerJan LuhaSona WimmerovaPetra MatalovaPeter KukumbergJan MurinTomas TesarBeata HavelkovaRashmi Shah;

  • 作者单位

    Institute of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Comenius University;

    General Health Insurance Company;

    Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, ComeniusDepartment of Biophysics, Informatics and Biostatistics, Faculty of Public Health, Slovak MedicalDepartment of Pharmacology, Faculty of Medicine and Dentistry, Palacky University2nd Department of Neurology, Faculty of Medicine, Comenius University1st Department of Internal Medicine, Faculty of Medicine, Comenius UniversityDepartment of Organisation and Management of Pharmacy, Faculty of Pharmacy, Comenius UniversityIndependent Pharmaceutical Consultant;

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  • 正文语种 英语
  • 中图分类 药学;
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