Thymidylate synthase as an oncogene?

Bertino JR; Banerjee D

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Thymidylate synthase as an oncogene?

机译：胸苷酸合酶是一种癌基因吗？

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A surprising finding in the report by Rahman et al. in this issue of Cancer Cell is that forced overexpression of human thymidylate synthase transforms immortalized murine cells into a malignant phenotype. We discuss the possibility that elevated levels of thymidylate synthase noted in some human malignancies may contribute to tumor progression and may also reflect increased levels of its transcriptional activator E2F-1.

机译：Rahman等人的报告中有一个令人惊讶的发现。本期《癌细胞》杂志的一篇文章指出，人胸苷酸合酶的强制过表达将永生化的鼠细胞转化为恶性表型。我们讨论了在某些人类恶性肿瘤中发现的胸苷酸合酶水平升高可能有助于肿瘤进展，也可能反映了其转录激活因子E2F-1水平升高的可能性。

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《Cancer Cell》 |2004年第4期|共2页
作者
Bertino JR; Banerjee D;
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正文语种 eng
中图分类肿瘤学;
关键词
Thymidylate Synthase; Malignant Neoplasms; Oncogenes; Human; E2F1 Gene; 癌基因;

机译：胸苷酸合酶;恶性肿瘤;致癌基因;人类;E2F1基因;癌基因;

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专利

1. Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme. [J] . Rahman L, Voeller D, Rahman M, Cancer Cell . 2004,第4期

机译：胸苷酸合酶是一种癌基因：必需的DNA合成酶的新作用。
2. The pemetrexed-containing treatments in the non-small cell lung cancer, is -/low thymidylate synthase expression better than +/high thymidylate synthase expression: a meta-analysis [J] . Lei Wang, Rui Wang, Yunjian Pan, BMC Cancer . 2014,第1期

机译：非小细胞肺癌中含培美曲塞的治疗方法是-/胸苷酸合酶低表达优于+ /胸苷酸合酶高表达：荟萃分析
3. Trichinella pseudospiralis vs. T. spiralis thymidylate synthase gene structure and T. pseudospiralis thymidylate synthase retrogene sequence [J] . El?bieta Jagielska, Andrzej P?ucienniczak, Magdalena D?browska, Parasites Vectors . 2014,第S1期

机译：旋毛虫三角螺旋体vs.螺旋螺旋体胸苷酸合酶基因结构和伪螺旋体胸苷酸合酶逆转录基因序列
4. Effect of 5-fluorouracil on the regulation of zebrafish thymidylate synthase gene expression [C] . Chunxia Song, Qian Zhang, Yuliang Xiao International conference on biotechnology, chemical and materials engineering . 2013

机译：5-氟尿嘧啶对斑马鱼胸苷酸合酶基因表达调控的影响
5. Probing Subunit Communication Via a Singly Ligated State of Dimeric Thymidylate Synthase. [D] . Falk, Bradley T. 2017

机译：通过二聚体胸苷酸合酶的单连接状态探测亚基通讯。
6. Trichinella pseudospiralis vs. T. spiralis thymidylate synthase gene structure and T. pseudospiralis thymidylate synthase retrogene sequence [O] . Elżbieta Jagielska, Andrzej Płucienniczak, Magdalena Dąbrowska, 2014

机译：旋毛虫旋毛虫对螺旋体胸苷酸合酶基因结构和拟螺旋体胸苷酸合酶逆转录基因序列
7. Thymidylate synthase as an oncogene A novel role for an essential DNA synthesis enzyme [O] . Rahman Lambratu, Voeller Donna, Rahman Monzur, 2004

机译：胸苷酸合酶作为致癌基因必需的DNA合成酶的新作用

Thymidylate synthase as an oncogene?

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