Antrolone, a Novel Benzoid Derived from Antrodia cinnamomea, Inhibits the LPS-Induced Inflammatory Response in RAW264.7 Macrophage Cells by Balancing the NF-kappa B and Nrf2 Pathways

Yen I-Chuan; Shi Li-Shian; Chung Min-ChiehAhmetaj-Shala BlerinaChang Tsu-ChungLee Shih-Yu

首页> 外文期刊>The American journal of Chinese medicine >Antrolone, a Novel Benzoid Derived from Antrodia cinnamomea, Inhibits the LPS-Induced Inflammatory Response in RAW264.7 Macrophage Cells by Balancing the NF-kappa B and Nrf2 Pathways

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Antrolone, a Novel Benzoid Derived from Antrodia cinnamomea, Inhibits the LPS-Induced Inflammatory Response in RAW264.7 Macrophage Cells by Balancing the NF-kappa B and Nrf2 Pathways

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Antrodia cinnamomea, a medicinal mushroom, has previously demonstrated anti-inflammatory activity, although the specific compound responsible for the effect remains unclear. The present study was designed to investigate the anti-inflammatory property of antrolone, a novel benzoid derived from A. cinnamomea mycelium, and to clarify the underlying mechanisms of action. To this end, murine macrophage RAW264.7 cells were treated with antrolone (0.1-30 mu M) 30 min prior to stimulation with lipopolysaccharides (LPS, 0.1 mu g/ml) for 24h. Cell viability, nitric oxide (NO) and prostaglandin E-2 (PGE(2)) production, levels of pro-inflammatory cytokines and chemokines, and the signaling pathways involved in the inflammatory cascades were then investigated. Our results show that antrolone significantly decreased LPS-induced NO, PGE(2), pro-inflammatory cytokine, and keratinocyte chemoattractant CXCL1 (KC) production and reduced levels of the proteins inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). These effects were independent of the effect of antrolone on macrophage cytotoxicity. Moreover, antrolone significantly inhibited the activation of the NF kappa B, MAPK, and AKT pathways, while it increased nuclear factor erythroid-2-related factor (Nrf2) and heme oxygenase-1 (HO-1) levels. Our findings suggest that antrolone exhibits potent anti-inflammatory activity and may, therefore, be a lead compound for the development of an anti-inflammatory drug.

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《The American journal of Chinese medicine》 |2018年第6期|1297-1313|共17页
作者
Yen I-Chuan; Shi Li-Shian; Chung Min-ChiehAhmetaj-Shala BlerinaChang Tsu-ChungLee Shih-Yu;
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作者单位

Imperial Coll London, Natl Heart & Lung Inst, London, England;

Natl Def Med Ctr, Dept Biochem, Taipei, Taiwan;

Natl Def Med Ctr, Grad Inst Aerosp & Undersea Med, POB 90048-514, Taipei 114, TaiwanNatl Def Med Ctr, Sch Pharm, Taipei, TaiwanNatl Formosa Univ, Dept Biotechnol, Huwei, Yunlin, Taiwan;

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正文语种英语
中图分类中国医学;
关键词
Antrodia cinnamomea Mycelium; Macrophage; Inflammation; NF-kb; Nrf2;

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Antrolone, a Novel Benzoid Derived from Antrodia cinnamomea, Inhibits the LPS-Induced Inflammatory Response in RAW264.7 Macrophage Cells by Balancing the NF-kappa B and Nrf2 Pathways

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