A Novel Link between Inflammation and Cancer

Grinberg-Bleyer Yenkel; Ghosh Sankar

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A Novel Link between Inflammation and Cancer

机译：炎症与癌症之间的新颖联系

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Immune checkpoint-blockade treatments targeting PD-1/PD-L1 have revolutionized cancer therapy. Hence, understanding the regulation of PD-L1 expression has major clinical relevance. In this issue of Cancer Cell, Lim et al. report that inflammation-induced and NF-kappa B-driven expression of deubiquitinating enzyme CSN5 leads to PD-L1 stabilization and immune suppression in tumors.

机译：针对PD-1 / PD-L1的免疫检查点封锁疗法彻底改变了癌症治疗方法。因此，了解PD-L1表达的调控具有重大的临床意义。在本期《癌细胞》中，Lim等人。报告指出，炎症诱导的和NF-κB驱动的去泛素化酶CSN5的表达导致肿瘤中PD-L1的稳定和免疫抑制。

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《Cancer Cell》 |2016年第6期|共2页
作者
Grinberg-Bleyer Yenkel; Ghosh Sankar;
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正文语种 eng
中图分类肿瘤学;
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1. RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer [J] . Ohad Tarcic, Ioannis?S. Pateras, Tomer Cooks, Cell Reports . 2016,第6期

机译：RNF20将组蛋白H2B泛素化与炎症和与炎症相关的癌症联系起来
2. Pro-oncogenic role of alternative p38 mitogen-activated protein kinases p38γ and p38δ, linking inflammation and cancer in colitis-associated colon cancer [J] . DelReinoP., Alsina-BeauchampD., EscósA., Cancer research: The official organ of the American Association for Cancer Research, Inc . 2014,第21期

机译：替代性p38促分裂原活化蛋白激酶p38γ和p38δ的促癌作用，与结肠炎相关的结肠癌中的炎症和癌症相关
3. Cancer: IL-22: Linking inflammation and cancer [J] . Nature reviews Drug discovery . 2013,第7期

机译：癌症：IL-22：将炎症与癌症联系起来
4. An epigenetic switch involving a positive feedback loop linking inflammation to cancer effected by Myc and miRNA-17-92 microRNA cluster [C] . Chang Jichun, Wang Ruiqi International Conference on Systems Biology . 2014

机译：表观遗传开关涉及由Myc和miRNA-17-92 microRNA簇影响的将炎症与癌症联系起来的正反馈回路
5. Linking Inflammation To Tumorigenesis In A Mouse Model of High Fat Diet-Enhanced Colon Cancer: Does Fat Type Matter? [D] . Day, Stani Dellyn. 2012

机译：在高脂饮食增强结肠癌的小鼠模型中将炎症与肿瘤发生联系起来：脂肪类型重要吗？
6. RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer [O] . Ohad Tarcic, Ioannis S. Pateras, Tomer Cooks, -1

机译：RNF20将组蛋白H2B泛素化与炎症和与炎症相关的癌症联系起来
7. RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer [O] . Ohad Tarcic, Ioannis S. Pateras, Tomer Cooks, 2016

机译：RNF20将组蛋白H2B泛素化与炎症和炎症相关的癌症联系起来

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A Novel Link between Inflammation and Cancer

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