What has senescence got to do with cancer?

Dimri GP

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What has senescence got to do with cancer?

机译：衰老与癌症有什么关系？

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Cancer therapeutics are primarily thought to work by inducing apoptosis in tumor cells. However, various tumor suppressors and oncogenes have been shown to regulate senescence in normal cells, and senescence bypass appears to be an important step in the development of cancer. Cellular senescence limits the replicative capacity of cells, thus preventing the proliferation of cells that are at different stages of malignancy. A recent body of evidence suggests that induction of senescence can be exploited as a basis for cancer therapy.

机译：癌症治疗剂主要被认为通过诱导肿瘤细胞凋亡来发挥作用。但是，已显示出各种肿瘤抑制因子和致癌基因可调节正常细胞的衰老，而衰老旁路似乎是癌症发展中的重要一步。细胞衰老限制了细胞的复制能力，从而阻止了处于不同恶性阶段的细胞的增殖。最近的证据表明，可以将诱导衰老用作癌症治疗的基础。

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《Cancer Cell》 |2005年第6期|共8页
作者
Dimri GP;
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正文语种 eng
中图分类肿瘤学;
关键词
Senescence; Malignant Neoplasms; cancer therapy; bypass;

机译：衰老;恶性肿瘤;癌症治疗;旁路;

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1. Synthetic Resveratrol Analogue, 3,3',4,4',5,5'-Hexahydroxy-trans-Stilbene, Accelerates Senescence in Peritoneal Mesothelium and Promotes Senescence-Dependent Growth of Gastrointestinal Cancers [J] . Justyna Miku#x00142, a-Pietrasik, Katarzyna Piwocka, International Journal of Molecular Sciences . 2013,第11期

机译：合成白藜芦醇类似物3,3'，4,4'，5,5'-六羟基反式-Stilbene加速腹膜上皮的衰老并促进衰老依赖的胃肠道肿瘤的生长
2. Insight into the role of PIKK family members and NF-кB in DNAdamage-induced senescence and senescence-associated secretory phenotype of colon cancer cells [J] . Anna Strzeszewska, Olga Alster, Gra?yna Mosieniak, Cell death & disease. . 2018,第2期

机译：深入了解PIKK家族成员和NF-кB在DNA损伤诱导的结肠癌细胞衰老及与衰老相关的分泌表型中的作用
3. Insight into the role of PIKK family members and NF-кB in DNAdamage-induced senescence and senescence-associated secretory phenotype of colon cancer cells [J] . Anna Strzeszewska, Olga Alster, Gra?yna Mosieniak, Cell death & disease. . 2018,第2期

机译：深入了解PIKK家族成员和NF-кB在DNA损伤诱导的结肠癌细胞衰老及与衰老相关的分泌表型中的作用
4. Gene expression analysis of genes involved in bypassing cellular senescence in prostate cancer [C] . Neha Som Nath Puri, Niravath Geethu Issac, Shipra Vinodkumar Gupta, International Conference on Bioinformatics and Computational Biology . 2010

机译：绕过前列腺癌中绕过细胞衰老的基因基因表达分析
5. Identification of Molecular Determinants of Cellular Senescence in Cancer and Aging [D] . Yuan, Lifeng 2018

机译：癌症和衰老中细胞衰老的分子决定因素的鉴定
6. Synthetic Resveratrol Analogue 33′44′55′-Hexahydroxy-trans-Stilbene Accelerates Senescence in Peritoneal Mesothelium and Promotes Senescence-Dependent Growth of Gastrointestinal Cancers [O] . Justyna Mikuła-Pietrasik, Patrycja Sosińska, Marcin Wierzchowski, 2013

机译：合成白藜芦醇类似物334455-六羟基反式-Stilbene促进腹膜上皮的衰老并促进衰老依赖的胃肠道肿瘤的生长
7. Synthetic Resveratrol Analogue, 3,3',4,4',5,5'-Hexahydroxy-trans-Stilbene, Accelerates Senescence in Peritoneal Mesothelium and Promotes Senescence-Dependent Growth of Gastrointestinal Cancers [O] . Krzysztof Książek, Marcin Wierzchowski, Katarzyna Piwocka, 2013

机译：合成的白藜芦醇类似物，3,3＆＃039;，4,4＆＃039;，5,5＆＃039; - 羟基 - 反式 - 二苯乙烯，加速腹膜间皮细胞的衰老并促进胃肠道癌症的衰老依赖性生长。

What has senescence got to do with cancer?

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