Macrophage Activation Syndrome (MAS) and thrombotic thrombocytopenic purpura (TTP) - Are they from a single spectrum?

Owlia M.B.; Soleimani H.; Mortazavizadeh M.R.

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Macrophage Activation Syndrome (MAS) and thrombotic thrombocytopenic purpura (TTP) - Are they from a single spectrum?

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Macrophage Activation Syndrome is a life-threatening condition of special rheumatologic disorders secondary to activation of massive number of lymphocytes and macrophages. It is a severe complication of childhood systemic inflammatory disorders primarily systemic type juvenile rheumatoid arthritis and occasionally systemic lupus erythematosus. Clinical manifestations, laboratory parameters and outcome are very similar to thrombotic thrombocytopenic purpura so that we suggest the terminology of autoimmune-based TTP as an equivalent for macrophage activation syndrome (MAS). Herein we describe a 21 year-old-girl patient with adult onset Still's disease (AOSD) complicated with 'TTP-MAS syndrome' and successfully treated with plasmapheresis, steroid and cyclosporine A.

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《journal, indian academy of clinical medicine》 |2005年第4期|337-340|共页
作者
Owlia M.B.; Soleimani H.; Mortazavizadeh M.R.;
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Division of Rheumatology Department of Medicine Sadoughi University of Medical Sciences;

Division of Hemato-oncology Department of Medicine Sadoughi University of Medical Sciences;

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正文语种英语
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Adult onset Still's disease (AOSD); Disseminated intravascular coagulopathy (DIC); Macrophage activation syndrome (MAS); Thrombotic thrombocytopenic purpura (TTP);

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Macrophage Activation Syndrome (MAS) and thrombotic thrombocytopenic purpura (TTP) - Are they from a single spectrum?

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