Endoplasmic Reticulum Stress in Malignancy

ClarkeH.J.; ChambersJ.E.; LinikerE.; MarciniakS.J.

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Endoplasmic Reticulum Stress in Malignancy

机译：恶性肿瘤的内质网应激

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The combination of relative nutrient deprivation and dysregulation of protein synthesis make malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which results from protein misfolding within the secretory pathway, has a profound effect on cancer cell proliferation and survival. In this review, we examine the evidence implicating endoplasmic reticulum dysfunction in the pathology of cancer and discuss how recent findings may help to identify novel therapeutic targets.

机译：相对营养剥夺和蛋白质合成失调的结合使恶性细胞特别容易发生蛋白质错误折叠。内质网应激是由分泌途径中的蛋白质错误折叠引起的，对癌细胞的增殖和存活具有深远的影响。在这篇综述中，我们检查了在癌症病理中涉及内质网功能障碍的证据，并讨论了最近的发现如何帮助确定新的治疗靶标。

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《Cancer Cell》 |2014年第5期|共11页
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ClarkeH.J.; ChambersJ.E.; LinikerE.; MarciniakS.J.;
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正文语种 eng
中图分类肿瘤学;
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Endoplasmic Reticulum Stress in Malignancy

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