Risk comparison for prenatal use of analgesics and selected birth defects, National Birth Defects Prevention Study 1997–2011

Julia D. Interrante; Elizabeth C. Ailes; Jennifer N. LindMarlene AnderkaMarcia L. FeldkampMartha M. WerlerLockwood G. TaylorJames TrinidadSuzanne M. GilboaCheryl S. Broussard

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Risk comparison for prenatal use of analgesics and selected birth defects, National Birth Defects Prevention Study 1997–2011

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Abstract Purpose To compare the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and/or opioids to the use of acetaminophen without NSAIDs or opioids with respect to associations with birth defects. Methods We used data from the National Birth Defects Prevention Study (1997–2011). Exposure was self-reported maternal analgesic use from the month before through the third month of pregnancy (periconceptional). Adjusted odds ratios (aORs) were calculated to examine associations with 16 birth defects. Results Compared to acetaminophen, mothers reporting NSAIDs were significantly more likely to have offspring with gastroschisis, hypospadias, cleft palate, cleft lip with cleft palate, cleft lip without cleft palate, anencephaly, spina bifida, hypoplastic left heart syndrome, pulmonary valve stenosis, and tetralogy of Fallot (aOR range, 1.2–1.6). Opioids were associated with tetralogy of Fallot, perimembranous ventricular septal defect, and ventricular septal defect with atrial septal defect (aOR range, 1.8–2.3), whereas use of both opioids and NSAIDs was associated with gastroschisis, cleft palate, spina bifida, hypoplastic left heart syndrome, and pulmonary valve stenosis (aOR range, 2.0–2.9). Conclusions Compared to periconceptional use of acetaminophen, selected birth defects occurred more frequently among infants of women using NSAIDs and/or opioids. However, we could not definitely determine whether these risks relate to the drugs or to indications for treatment.

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来源
《Annals of epidemiology》 |2017年第10期|645-653|共9页
作者
Julia D. Interrante; Elizabeth C. Ailes; Jennifer N. LindMarlene AnderkaMarcia L. FeldkampMartha M. WerlerLockwood G. TaylorJames TrinidadSuzanne M. GilboaCheryl S. Broussard;
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作者单位

Birth Defects Monitoring Program, Center for Birth Defects Research and Prevention, Massachusetts;

Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine;

Department of Epidemiology, School of Public Health, Boston UniversityDivision of Congenital and Developmental Disorders, National Center on Birth Defects andDivision of Epidemiology, Office of Surveillance and Epidemiology, Center for Drug Evaluation and;

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原文格式 PDF
正文语种英语
中图分类流行病学与防疫;
关键词
Congenital abnormalities; Pregnancy; Teratogens; Analgesics; Opioids; Acetaminophen; Anti-inflammatory agents; Nonsteroidal;

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Risk comparison for prenatal use of analgesics and selected birth defects, National Birth Defects Prevention Study 1997–2011

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