Burkitt Lymphoma: Much More than MYC

Dominguez-SolaD.; Dalla-FaveraR.

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Burkitt Lymphoma: Much More than MYC

机译：伯基特淋巴瘤：比MYC还多

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Chromosomal translocations causing deregulated c-MYC expression are detectable in most Burkitt lymphoma cases. However, little is known about the additional lesions necessary for lymphomagenesis. Now, two independent studies, one of which was performed by Sander et al. in this issue of Cancer Cell, identify constitutive PI3K signaling and CyclinD3 mutations as cooperating lesions in both mice and humans. The results have directly actionable therapeutic implications.

机译：在大多数伯基特淋巴瘤病例中均可检测到导致c-MYC表达失控的染色体易位。但是，对于淋巴瘤发生所必需的其他损伤知之甚少。现在，有两项独立的研究，其中一项是由Sander等人进行的。在本期《癌细胞》中，将组成型PI3K信号传导和CyclinD3突变确定为小鼠和人类的协同病变。结果具有直接可操作的治疗意义。

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《Cancer Cell》 |2012年第2期|共2页
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Dominguez-SolaD.; Dalla-FaveraR.;
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正文语种 eng
中图分类肿瘤学;
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1. The 11q-Gain/Loss Aberration Occurs Recurrently in MYC-Negative Burkitt-like Lymphoma With 11q Aberration, as Well as MYC-Positive Burkitt Lymphoma and MYC-Positive High-Grade B-Cell Lymphoma, NOS [J] . Grygalewicz Beata, Woroniecka Renata, Rymkiewicz Grzegorz, American journal of clinical pathology. . 2018,第1期

机译：11Q - 增益/损失像差在Myc阴性Burkitt样淋巴瘤中发生常用，具有11q像畸变，以及Myc阳性Burkitt淋巴瘤和Myc阳性高级B细胞淋巴瘤，NOS
2. Contribution of immunophenotype to the investigation and differential diagnosis of Burkitt lymphoma, double-hit high-grade B-cell lymphoma, and single-hit MYC-rearranged diffuse large B-cell lymphoma [J] . Tsagarakis Nikolaos J., Papadhimitriou Stefanos I, Pavlidis Dimitris, Cytometry, Part B. Clinical cytometry: the journal of the International Society for Analytical Cytology . 2020,第5期

机译：免疫蛋白型对Burkitt淋巴瘤的调查和鉴别诊断，双击高级B细胞淋巴瘤和单次myc重新排列的弥漫性大B细胞淋巴瘤的贡献
3. Transformation of Follicular Lymphoma to a High-Grade B-Cell Lymphoma With MYC and BCL2 Translocations and Overlapping Features of Burkitt Lymphoma and Acute Lymphoblastic Leukemia: A Case Report and Literature Review [J] . Alina M Bischin, Russell Dorer, David M Aboulafia Clinical Medicine Insights: Blood Disorders . 2017,第8期

机译：滤泡性淋巴瘤向MYC和BCL2易位并具有伯基特淋巴瘤和急性淋巴细胞白血病的重叠特征的高级B细胞淋巴瘤的转化：病例报告和文献综述
4. Potency Fraction Ethyl Acetat of Myrmecodia pendans Merr Perry On Apoptosis Induction of malignant Burkitt's Lymphoma Oral Cell In Vitro [C] . Ana Medawati, Supriatno, Sofia Mubarika, International Conference on Bioinformatics and Nanomedicine from Natural Resources for Biomedical Research . 2019

机译：Myrmecodia pendans Merr＆Perry对Matignant Burkitt在体外凋亡诱导的效力分数
5. Reactivation of Epstein-Barr Virus in Burkitt Lymphoma Cells in Response to Histone Deacetylase Inhibitors [D] . Daigle, Derek Alan 2011

机译：响应组蛋白脱乙酰基酶抑制剂的伯基特淋巴瘤细胞中爱泼斯坦-巴尔病毒的重新激活。
6. The 11q-Gain/Loss Aberration Occurs Recurrently in MYC-Negative Burkitt-like Lymphoma With 11q Aberration as Well as MYC-Positive Burkitt Lymphoma and MYC-Positive High-Grade B-Cell Lymphoma NOS [O] . Beata Grygalewicz, Renata Woroniecka, Grzegorz Rymkiewicz, -1

机译：11q畸变的MYC阴性伯基特样淋巴瘤MYC阳性伯基特淋巴瘤和MYC阳性高级别B细胞淋巴瘤NOS反复发生11q增益/丢失畸变。
7. Value of CD44 immunostaining (IHC) as a surrogate in the differentiation of MYC-positive Burkitt lymphoma (BL) and Burkitt lymphoma-like (BLL) from MYC-negative Diffuse Large B-Cell Lymphoma (DLBCL) in a resource constrained clinical setting [O] . 2009

机译：CD44免疫染色（IHC）作为MYR阴性弥漫性大B细胞淋巴瘤（DLBCL）从MYC阴性弥漫性大B细胞淋巴瘤（DLBCL）分化成MYC阳性Burkitt淋巴瘤（BL）和Burkitt淋巴瘤样（BLL）的替代物的价值

Burkitt Lymphoma: Much More than MYC

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