Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study

Pospisil Petr; Kazda Tomas; Hynkova LudmilaBulik MartinDobiaskova MarieBurkon PetrLaack Nadia N.Slampa PavelJancalek Radim

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Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study

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Background and purpose: The aim of this prospective study is to evaluate post -whole brain radiotherapy (WBRT) changes in hippocampal concentration of N-acetylaspartate (h-tNAA) as a marker of neuronal loss and to correlate those changes to neurocognitive function.

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《Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology》 |2017年第3期|373-379|共7页
作者
Pospisil Petr; Kazda Tomas; Hynkova LudmilaBulik MartinDobiaskova MarieBurkon PetrLaack Nadia N.Slampa PavelJancalek Radim;
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作者单位

Masaryk Univ, Dept Radiat Oncol, Fac Med, Brno, Czech Republic;

St Annes Univ Hosp Brno, Dept Clin Psychol, Brno, Czech Republic;

Mayo Clin, Dept Radiat Oncol, Rochester, MN USASt Annes Univ Hosp Brno, Masaryk Univ, Fac Med, Dept Neurosurg, Brno, Czech RepublicSt Annes Univ Hosp Brno, Dept Diagnost Imaging, Brno, Czech Republic;

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原文格式 PDF
正文语种英语
中图分类肿瘤学;
关键词
Hippocampus; Radiation injury; Neurocognitive function; Magnetic resonance spectroscopy;

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Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study

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