Infectivity of Plasmodium falciparum in Malaria-Naive Individuals Is Related to Knob Expression and Cytoadherence of the Parasite

Stanisic Danielle I.; Gerrard John; Fink JamesGriffin Paul M.Liu Xue Q.Sundac LanaSekuloski SilvanaRodriguez Ingrid B.Pingnet JolienYang YuedongZhou YaoqiTrenholme Katharine R.Wang Claire Y. T.Hackett HazelChan Jo-Anne A.Langer ChristineHanssen EricHoffman Stephen L.Beeson James G.McCarthy James S.Good Michael F.

首页> 外文期刊>Infection and immunity. >Infectivity of Plasmodium falciparum in Malaria-Naive Individuals Is Related to Knob Expression and Cytoadherence of the Parasite

【24h】

Infectivity of Plasmodium falciparum in Malaria-Naive Individuals Is Related to Knob Expression and Cytoadherence of the Parasite

机译：

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Plasmodium falciparum is the most virulent human malaria parasite because of its ability to cytoadhere in the microvasculature. Nonhuman primate studies demonstrated relationships among knob expression, cytoadherence, and infectivity. This has not been examined in humans. Cultured clinical-grade P. falciparum parasites (NF54, 7G8, and 3D7B) and ex vivo-derived cell banks were characterized. Knob and knob-associated histidine-rich protein expression, CD36 adhesion, and antibody recognition of parasitized erythrocytes (PEs) were evaluated. Parasites from the cell banks were administered to malaria-naive human volunteers to explore infectivity. For the NF54 and 3D7B cell banks, blood was collected from the study participants for in vitro characterization. All parasites were infective in vivo. However, infectivity of NF54 was dramatically reduced. In vitro characterization revealed that unlike other cell bank parasites, NF54 PEs lacked knobs and did not cytoadhere. Recognition of NF54 PEs by immune sera was observed, suggesting P. falciparum erythrocyte membrane protein 1 expression. Subsequent recovery of knob expression and CD36-mediated adhesion were observed in PEs derived from participants infected with NF54. Knobless cell bank parasites have a dramatic reduction in infectivity and the ability to adhere to CD36. Subsequent infection of malaria-naive volunteers restored knob expression and CD36-mediated cytoadherence, thereby showing that the human environment can modulate virulence.

著录项

来源
《Infection and immunity.》 |2016年第9期|2689-2696|共8页
作者
Stanisic Danielle I.; Gerrard John; Fink JamesGriffin Paul M.Liu Xue Q.Sundac LanaSekuloski SilvanaRodriguez Ingrid B.Pingnet JolienYang YuedongZhou YaoqiTrenholme Katharine R.Wang Claire Y. T.Hackett HazelChan Jo-Anne A.Langer ChristineHanssen EricHoffman Stephen L.Beeson James G.McCarthy James S.Good Michael F.;
展开▼
作者单位

Griffith Univ, Inst Glyc, Southport, Qld, Australia;

Univ Queensland, QIMR Berghofer Med Res Inst, Clin Trop Med Lab, Herston, Qld, Australia;

Ctr Childrens Hlth Res, Queensland Paediat Infect Dis Lab, South Brisbane, Qld, AustraliaMacfarlane Burnet Inst Med Res & Publ Hlth, Melbourne, Vic, AustraliaUniv Melbourne, Adv Microscopy Facil, Mol Sci & Biotechnol Inst Bio21, Melbourne, Vic, AustraliaUniv Queensland, Sch Med, Herston, Qld, AustraliaGold Coast Univ Hosp, Southport, Qld, AustraliaQ Pharm Pty Ltd, Herston, Qld, AustraliaSanaria Inc, Gaithersburg, MD USA;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类传染病;
关键词

相似文献

外文文献
中文文献
专利

1. Multiple stiffening effects of nanoscale knobs on human red blood cells infected with Plasmodium falciparum malaria parasite [J] . Zhang Yao, Huang Changjin, Kim SangtaeGolkaram MahdiDixon Matthew W. A.Tilley LeannLi JuZhang SulinSuresh Subra Proceedings of the National Academy of Sciences of the United States of America . 2015,第19期

机译：Multiple stiffening effects of nanoscale knobs on human red blood cells infected with Plasmodium falciparum malaria parasite
2. Flow Cytometric Sorting of Infected Erythrocytes Demonstrates Reliable Detection of Individual Ring-Stage Plasmodium falciparum Parasites by Plasmodium 18S rRNA Reverse Transcription Polymerase Chain Reaction [J] . Matsubara Jokichi, Chang Ming, Seilie Annette M.Murphy Sean C. The American Journal of Tropical Medicine and Hygiene . 2022,第6期

机译：Flow Cytometric Sorting of Infected Erythrocytes Demonstrates Reliable Detection of Individual Ring-Stage Plasmodium falciparum Parasites by Plasmodium 18S rRNA Reverse Transcription Polymerase Chain Reaction
3. Plasmodium chabaudi: a rodent malaria model for in‐vivo and in‐vitro cytoadherence of malaria parasites in the absence of knobs [J] . J. COX, S. SEMOFF, M. HOMMEL parasite immunology . 1987,第5期

机译：Plasmodium chabaudi: a rodent malaria model for in‐vivo and in‐vitro cytoadherence of malaria parasites in the absence of knobs
4. A fast and accurate detection of Schizont plasmodium falciparum using channel color space segmentation method [C] . S Edy Victor Haryanto, M. Y. Mashor, A. S. Abdul Nasir, International Conference on Cyber and IT Service Management . 2017

机译：使用信道颜色空间分割方法快速准确地检测Schizont Plasmodium Falciparum
5. Attenuated P. falciparum Parasite Shows Cytokine Variations in Humanized Mice [O] . Lei-lei Zhang, Jin-Long Li, Ming-Xin Ji, 2020

机译：减毒的p. falciparum parasite显示人源化小鼠的细胞因子变化
6. Malária grave por Plasmodium falciparum Severe Plasmodium falciparum malaria [O] . Andréia Patrícia Gomes, Rodrigo Roger Vitorino, Anielle de Pina Costa, 2011

机译：malária严重恶性疟原虫（plasmodium falciparum）恶性恶性疟原虫（plasmodium falciparum）疟疾
7. Guanosine Triphosphate Cyclohydrolase in Plasmodium falciparum and other Plasmodium Species [R] . Krungkrai, J., Yuthavong, Y., Webster, H. K. 1985

机译：三叶草（plasmodium falciparum）和其他疟原虫（plasmodium）物种中的鸟苷三磷酸环化水解酶

Infectivity of Plasmodium falciparum in Malaria-Naive Individuals Is Related to Knob Expression and Cytoadherence of the Parasite

摘要

著录项

相似文献

相关主题

期刊订阅