Unexplained fever and B-symptoms in a young male Black African

Weber T.; Ettrich T.; Christopeit M.Lindner A.Holzhausen H. J.Oehme A.Arnold D.Wolf H. H.Luebbert C.Kekule A. S.Schmoll H. J.Werdan K.Ebelt H.

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Unexplained fever and B-symptoms in a young male Black African

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abstract_textpAn immunocompetent Nigerian developed a fulminant hemophagocytic lymphohistiocytosis due to Epstein-Barr virus reactivation. The patient initially presented with fever, hepatosplenomegaly and pancytopenia. The clinical status of our patient deteriorated quickly despite treatment with corticoids. Escalation of immunosuppressive treatment was not possible. He died of lung, liver and circulatory failure in our intensive care unit./ppHemophagocytic lymphohistiocytosis is a rare disease characterized by inflammation due to prolonged and excessive activation of antigen-presenting cells. High plasma ferritin levels and phagocytosis of hematopoetic cells in bone marrow, spleen and liver lead to the diagnosis. Hemophagocytic lympho-histiocytosis should therefore be included in the differential diagnosis in patients with persistent fever, hepatosplenomegaly and cytopenia./p/abstract_text

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《Der Internist》 |2012年第1期|93-98|共6页
作者
Weber T.; Ettrich T.; Christopeit M.Lindner A.Holzhausen H. J.Oehme A.Arnold D.Wolf H. H.Luebbert C.Kekule A. S.Schmoll H. J.Werdan K.Ebelt H.;
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Univ Halle Wittenberg, Klin & Poliklin Innere Med 4, Univ Klinikum Halle Saale, D-06097 Halle, Saale, Germany;

Univ Halle Wittenberg, Klin & Poliklin Innere Med 1, Univ Klinikum Halle Saale, D-06097 Halle, Saale, Germany;

Univ Halle Wittenberg, Inst Pathol, Univ Klinikum Halle Saale, D-06097 Halle, Saale, GermanyUniv Halle Wittenberg, Inst Mikrobiol & Virol, Univ Klinikum Halle Saale, D-06097 Halle, Saale, GermanyUniv Halle Wittenberg, Klin & Poliklin Innere Med 3, Univ Klinikum Halle Saale, D-06097 Halle, Saale, Germany;

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正文语种英语
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Hemophagocytic lymphohistiocytosis; Hemophagocytosis syndrome; Epstein-Barr virus; Fever; Cytopenia; EPSTEIN-BARR-VIRUS; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; GUIDELINES; INFECTION;

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机译：A young child with fever and unexplained acute kidney injury: Answers
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机译：A young child with fever and unexplained acute kidney injury: Questions
3. Impact analysis of an evidence-based guideline on diagnosis of urinary tract infection in infants and young children with unexplained fever [J] . Dorien H. F. Geurts, Willem Vos, Henriette A. MollRianne Oostenbrink European journal of pediatrics . 2014,第4期

机译：Impact analysis of an evidence-based guideline on diagnosis of urinary tract infection in infants and young children with unexplained fever
4. RICKETTSIOSI DEL GRUPPO “SPOTTED FEVER” CONTRATTA IN SUD AFRICA [O] . F. Greco, A. Vallone, G. Apuzzo, 2003

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Unexplained fever and B-symptoms in a young male Black African

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