Albuminuria. Prognostic marker or therapeutic goal?

Chatzikyrkou C.; Haller H.; Menne J.

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Albuminuria. Prognostic marker or therapeutic goal?

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abstract_textpMicroalbuminuria has most often been linked with renal disease in diabetic patients. However, accumulating data demonstrate that the development of albuminuria is closely associated with cardiovascular and renal disease in both diabetic and non-diabetic patients. The role of albuminuria in the pathogenesis of these clinical conditions remains controversial. While reductions in albuminuria have been associated with improved outcomes, the evidence for lower levels of albuminuria (microalbuminuria and normoal-buminuria) is inconclusive. Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers have demonstrated some success in treating or delaying the onset of microalbuminuria. However, it remains to be established whether these effects result in meaningful reductions in clinical renal or cardiovascular events./p/abstract_text

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《Der Internist》 |2012年第1期|38-44|共7页
作者
Chatzikyrkou C.; Haller H.; Menne J.;
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Hannover Med Sch, Abt Nieren & Hochdruckerkrankungen, D-30625 Hannover, Germany;

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正文语种英语
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Albuminuria; Diabetic nephropathies; Renin-angiotensin system; Angiotensin II; type 1 receptor blockers; Angiotensin-converting enzyme inhibitors; GLOMERULAR-FILTRATION-RATE; LEFT-VENTRICULAR HYPERTROPHY; CHRONIC KIDNEY-DISEASE; HYPERTENSIVE PATIENTS; COLLABORATIVE METAANALYSIS; CARDIOVASCULAR-DISEASE; DIABETIC-NEPHROPATHY; RISK-FACTORS; END-POINT; ALL-CAUSE;

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Albuminuria. Prognostic marker or therapeutic goal?

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