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首页> 外文期刊>Mechanisms of Development >Vegf as an epithelial cell morphogen modulates branching morphogenesis of embryonic kidney by directly acting on the ureteric bud
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Vegf as an epithelial cell morphogen modulates branching morphogenesis of embryonic kidney by directly acting on the ureteric bud

机译：Vegf作为上皮细胞形态发生因子，通过直接作用于输尿管芽来调节胚胎肾脏的分支形态发生

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摘要

There is growing evidence that vascular endothelial growth factor (Vegf), a well-recognized angiogenic factor, plays a regulatory role in non-endothelial tissues such as neurons and epithelial cells. In the kidney Vegf receptors have been detected in proximal tubule cells of the adult kidney and Vegf has been show to stimulate branching morphogenesis of the developing kidney. In this study, using laser-microdissection as well as manual separation of the UB, we demonstrate that Vegf receptors are present in the ureteric bud (UB). Furthermore, we determine that Vegf stimulates UB branching in whole kidney explant that is mediated directly by signaling through Vegfr2. In addition, Vegf also induced branching response in isolated UBs that are free of the surrounding mesenchyme. These responses seem to be strictly dependent on the dose of Vegf such that higher doses are inhibitory while lower dose are stimulatory. These data place Vegf in a unique position of being able to modulate vascular as well as epithelial development in the embryonic kidney.
机译：越来越多的证据表明，血管内皮生长因子（Vegf）是一种公认​​的血管生成因子，在非内皮组织（如神经元和上皮细胞）中起调节作用。在肾脏中，已经在成年肾脏的近端肾小管细胞中检测到Vegf受体，并且已经显示Vegf刺激发育中的肾脏的分支形态发生。在这项研究中，使用激光显微切割以及手动分离UB，我们证明了输尿管芽（UB）中存在Vegf受体。此外，我们确定Vegf刺激通过Vegfr2信号直接介导的整个肾脏外植体中的UB分支。此外，Vegf还可以在不含周围间充质的分离的UBs中诱导分支反应。这些反应似乎严格取决于Vegf的剂量，因此较高的剂量具有抑制作用，而较低的剂量具有刺激作用。这些数据使Vegf处于能够调节胚胎肾脏中的血管以及上皮发育的独特位置。

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