Fibroin-Alginate Scaffold for Design of Floating Microspheres Containing Felodipine

Rathod Prashant; More Harinath; Dugam ShaileshVelapure PallaviJadhav Namdeo

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Fibroin-Alginate Scaffold for Design of Floating Microspheres Containing Felodipine

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Purpose The objective of present work was to develop fibroin-sodium alginate floating microspheres of felodipine (FD) showing modified release. Method Binary polymer system of fibroin-sodium alginate was used to prepare microspheres by spray drying technique. Thus, FD loaded microspheres obtained were evaluated for drug content, entrapment efficacy, particle size, micromeritics, FT-IR, DSC, XRD, floatability profile, mucoadhesion, in vitro drug release, and accelerated stability studies. Results The drug content of FD-loaded microspheres (F1-F5) was in the range of 68.55 +/- 1.20 to 78.21 +/- 0.54 and entrapment efficacy 45.93 +/- 0.41 to 61.60 +/- 0.72. The particle size varied from 60.33 +/- 0.64 to 66.87 +/- 0.85 mu m. Acceptable Carr's compressibility index and angle of repose demonstrated excellent flowability of microspheres (F1-F5). The FT-IR showed no chemical interactions between FD and polymers. The DSC and XRD indicated that FD was partially crystalline in microspheres. Floating parameters for optimized batch F2 were floating lag time10-15 s and floating time > 12 h. Floating buoyancy is 96.51 +/- 0.66. The in vitro drug dissolution kinetics of optimized F2 batch in 0.1NHCl and FSSGF demonstrated drug release up to 80.42 +/- 0.86 in 0.1NHCl and 84.64 +/- 0.30 in FSSGF following Peppas model. Conclusion Electrostatic repulsion between polymers successfully enabled the design of FD-loaded floating microspheres by spray drying. Excellent floating profile and extended release for 12 h, as per USFDA guidelines, have been demonstrated by the fibroin-sodium alginate binary composite system. In the future, fibroin-sodium alginate scaffold can be successfully used for tailor-made floating and release profiles of drugs belonging to different solubility classes.

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《journal of pharmaceutical innovation》 |2021年第2期|226-236|共11页
作者
Rathod Prashant; More Harinath; Dugam ShaileshVelapure PallaviJadhav Namdeo;
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Bharati Vidyapeeth Coll Pharm;

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正文语种英语
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Fibroin-sodium alginate microspheres; Floating; Sustained release; SYSTEM;

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Fibroin-Alginate Scaffold for Design of Floating Microspheres Containing Felodipine

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