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Establishment of porcine and monkey colonic organoids for drug toxicity study

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摘要

Pig and monkey are widely used models for exploration of human diseases and evaluation of drug efficiency and toxicity, but high cost limits their uses. Organoids have been shown to be promising models for drug test as they reasonably preserve tissue structure and functions. However, colonic organoids of pig and monkey are not yet established. Here, we report a culture medium to support the growth of porcine and monkey colonic organoids. Wnt signaling and PGE2 are important for long-term expansion of the organoids, and their withdrawal results in lineage differentiation to mature cells. Furthermore, we observe that porcine colonic organoids are closer to human colonic organoids in terms of drug toxicity response. Successful establishment of porcine and monkey colonic organoids would facilitate the mechanistic investigation of the homeostatic regulation of the intestine of these animals and is useful for drug development and toxicity studies.

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  • 来源
    《cell regeneration》 |2021年第1期|32-41|共10页
  • 作者

    Haonan Li; Yalong Wang; Mengxian ZhangHong WangAlong CuiJianguo ZhaoWeizhi JiYe-Guang Chen;

  • 作者单位

    The State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University;

    State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology;

    School of Life Sciences, University of Science and Technology of ChinaState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of SciencesUniversity of Chinese Academy of SciencesMax-Planck Center for Tissue Stem Cell Research and Regenerative Medicine, Guangzhou Regenerative Medicine and Health Guangdong Laboratory;

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  • 正文语种 英语
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  • 关键词

    Colonic organoids; Culture; Drug toxicity; Monkey; Pig;

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