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首页> 外文期刊>Egyptian Journal of Basic and Applied Sciences >Understanding the role of genetic susceptibility (ACE2 and TMPRSS2) in COVID-19
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Understanding the role of genetic susceptibility (ACE2 and TMPRSS2) in COVID-19

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摘要

ABSTRACT COVID-19-related morbidity and mortality are significantly increased with increasing age and the presence of co-existing health conditions, such as cancer and cardiovascular disease. While most infected people recover, even very young and otherwise healthy patients may unpredictably succumb to this disease. COVID-19 is highly susceptible to Angiotensin-converting enzyme 2 (ACE2) and Transmembrane protease-serine 2 (TMPRSS2) polymorphisms altering the angiotensinogen-ACE2 interactions, such as p. Arg514Gly and its prevalence. The article describes the role of understanding the genetic basis of COVID-19 and its susceptibility to human genes.

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    Healthy Africans Platform, Research and Development;

    Federal University of Agriculture;

    University of LagosUsman Danfodio UniversityNottingham Trent UniversityUniversity of ToledoUniversity of ArkansasUniversity of ToledoEkiti State UniversityTranslational Biology, Medicine and Health, Virginia TechIllinois State UniversityVillanova UniversityUka Tarsadia UniversityDamanhour University;

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  • 正文语种 英语
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  • 关键词

    Genetics; susceptibility; COVID-19; ACE2; TMPRSS2;

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