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首页> 外文期刊>Molecular imaging and biology: MIB : the official publication of the Academy of Molecular Imaging >Localization of deoxyglucose and annexin a5 in experimental atheroma correlates with macrophage infiltration but not lipid deposition in the lesion
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Localization of deoxyglucose and annexin a5 in experimental atheroma correlates with macrophage infiltration but not lipid deposition in the lesion

机译：实验性动脉粥样硬化中脱氧葡萄糖和膜联蛋白a5的定位与巨噬细胞浸润有关，但与病变中的脂质沉积无关

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Purpose: The aim of this study was to understand the relationship of lipid deposition to the macrophage content, macrophage metabolism, and apoptosis in plaque. We compared the uptake of 2-deoxy-2-fluoro-D-[ 14C]glucose ([ 14C]FDG) and [99m Tc]HYNIC-annexin V ([99m Tc] annexin A5) with the lesion histology in apolipoprotein E knockout (apoE -/-) mice. Procedures: Male apoE -/- mice (n=9) were injected with [ 14C]FDG and [99m Tc]annexin A5. Cryostat sections of aorta samples (n=49) were used for dual-tracer autoradiography, and regional tracer uptake levels were evaluated. Lesions were identified histologically with Movat's pentachrome (AHA lesion phenotypes), Mac-2 staining (macrophage infiltration) and Oil Red O staining (lipid deposition). Results: The highest uptakes of [ 14C]FDG (3.10±1.50 %ID×kilogram per square millimeter) and [99m Tc]annexin A5 (0.49±0.20 %ID×kilogram per square millimeter) were shown in atheromatous lesions (types III and IV). Each tracer uptake showed better correlation with macrophage infiltration than lipid deposition ([ 14C]FDG, r=0.44 vs. r=0.14; [99m Tc]annexin A5, r=0.65 vs. r=0.48). Conclusions: Both tracers were concentrated in type III and IV atheromatous lesions which corresponded to macrophage infiltration rather than lipid deposition.
机译：目的：本研究的目的是了解脂质沉积与斑块中巨噬细胞含量，巨噬细胞代谢和细胞凋亡的关系。我们比较了载脂蛋白E基因敲除对2-脱氧-2-氟-D- [14C]葡萄糖（[14C] FDG）和[99m Tc] HYNIC-annexin V（[99m Tc]膜联蛋白A5）的摄取。 （apoE-/-）小鼠。程序：向雄性apoE-/-小鼠（n = 9）注射[14C] FDG和[99m Tc] annexin A5。主动脉样本（n = 49）的低温恒温器切片用于双示踪放射自显影，并评估了局部示踪剂摄取水平。在组织学上通过Movat's五色色素（AHA病态表型），Mac-2染色（巨噬细胞浸润）和油红O染色（脂质沉积）鉴定病灶。结果：在动脉粥样硬化病变（III型和III型）中，[14C] FDG（3.10±1.50％ID×千克/平方毫米）和[99m Tc] annexin A5（0.49±0.20％ID×千克/平方毫米）具有最高吸收率。 IV）。示踪剂的摄取与脂质沉积相比，与巨噬细胞浸润的相关性更好（[14C] FDG，r = 0.44 vs. r = 0.14; [99m Tc] annexin A5，r = 0.65 vs.r = 0.48）。结论：两种示踪剂均集中在III型和IV型动脉粥样硬化病变中，这对应于巨噬细胞浸润而不是脂质沉积。

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