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首页> 外文期刊>journal of pharmaceutical innovation >Investigating the Effect of Particle Size on Cellular Uptake by Aggregation-Caused Quenching Probe-Encapsulating Solid Lipid Nanoparticles, Inhaled
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Investigating the Effect of Particle Size on Cellular Uptake by Aggregation-Caused Quenching Probe-Encapsulating Solid Lipid Nanoparticles, Inhaled

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Solid lipid nanoparticles (SLN) have been intensively exploited as nanocarriers for pulmonary drug delivery. However, no consensus on the underlying mechanisms between particle sizes and cell uptake behaviors was attained owing to their unclear in vivo fate after inhalation, which hindered the further development of a novel nanoparticle delivery system. Recently, aggregation-caused quenching (ACQ) probes had been developed to monitor the integrity of nanocarriers. In this study, an ACQ probe, P4, was employed to clarify the effect of particle size on SLN cellular uptake. SLN (120, 240, and 480 nm in size), incubated with epithelium cells (A549) and macrophages (RAW 264.7), mainly localized in the cytoplasm in an integrated pattern, showing a positive correlation relationship between particle size and cellular intake. In conclusion, this study established a firm basis to understand the effect of particle size on cellular uptake of nanoparticle systems and promoted the development of novel pulmonary drug delivery systems.

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