Discordance between chromatin accessibility and transcriptional activity during the human primed-to-naïve pluripotency transition process

Tu Z.; Bi Y.; Mao T.Wang H.Gao S.Wang Y.

首页> 外文期刊>cell regeneration >Discordance between chromatin accessibility and transcriptional activity during the human primed-to-naïve pluripotency transition process

【24h】

Discordance between chromatin accessibility and transcriptional activity during the human primed-to-naïve pluripotency transition process

机译：

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

© 2023, The Author(s).Naïve pluripotent state can be obtained by several strategies from various types of cells, in which the cell fate roadmap as well as key biological events involved in the journey have been described in detail. Here, we carefully explored the chromatin accessibility dynamics during the primed-to-naïve transition by adopting a dual fluorescent reporter system and the assay for transposase-accessible chromatin (ATAC)-seq. Our results revealed critical chromatin remodeling events and highlight the discordance between chromatin accessibility and transcriptional activity. We further demonstrate that the differential epigenetic modifications and transcription factor (TF) activities may play a critical role in regulating gene expression, and account for the observed variations in gene expression despite similar chromatin landscapes.

著录项

来源
《cell regeneration》 |2023年第1期|共页
作者
Tu Z.; Bi Y.; Mao T.Wang H.Gao S.Wang Y.;
展开▼
作者单位

Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine Shanghai East Hospital School of Life Sciences and Technology Tongji University;

Frontier Science Center for Stem Cell Research Tongji University;

Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital School of Life Sciences and Technology Tongji University;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类
关键词
Discordance between chromatin accessibility and transcriptional activity; Dual reporter system; Histone modifications; Naïve pluripotency; Primed-to-naïve transition;

相似文献

外文文献
中文文献

1. Unsupervised Machine Learning Identifies Chromatin Accessibility Regulatory Networks that Define Cell State Transitions in Pluripotency [J] . Robotics & Machine Learning Daily News . 2023,第1期

机译：Unsupervised Machine Learning Identifies Chromatin Accessibility Regulatory Networks that Define Cell State Transitions in Pluripotency
2. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome [J] . Hansen Tyler J., Hodges Emily Genome research . 2022,第8期

机译：ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome
3. Developmental Transcriptional Enhancers: A Subtle Interplay between Accessibility and Activity Considering Quantitative Accessibility Changes between Different Regulatory States of an Enhancer Deconvolutes the Complex Relationship between Accessibility and Activity [J] . Bozek Marta, Gompel Nicolas BioEssays : . 2020,第4期

机译：Developmental Transcriptional Enhancers: A Subtle Interplay between Accessibility and Activity Considering Quantitative Accessibility Changes between Different Regulatory States of an Enhancer Deconvolutes the Complex Relationship between Accessibility and Activity

Discordance between chromatin accessibility and transcriptional activity during the human primed-to-naïve pluripotency transition process

摘要

著录项

相似文献

相关主题

期刊订阅