Lung development and regeneration: newly defined cell types and progenitor status

Meng X.; Cui G.; Peng G.

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Lung development and regeneration: newly defined cell types and progenitor status

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© 2023, The Author(s).The lung is the most critical organ of the respiratory system supporting gas exchange. Constant interaction with the external environment makes the lung vulnerable to injury. Thus, a deeper understanding of cellular and molecular processes underlying lung development programs and evaluation of progenitor status within the lung is an essential part of lung regenerative medicine. In this review, we aim to discuss the current understanding of lung development process and regenerative capability. We highlight the advances brought by multi-omics approaches, single-cell transcriptome, in particular, that can help us further dissect the cellular player and molecular signaling underlying those processes.

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《cell regeneration》 |2023年第1期|共页
作者
Meng X.; Cui G.; Peng G.;
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Center for Cell Lineage and Development Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences;

Life Science and Medicine University of Science and Technology of China;

School of Basic Medical Sciences Guangzhou Laboratory Guangzhou Medical University;

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正文语种英语
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Lineage tracing; Lung development; Progenitor; Regeneration; scRNA-seq; Stem cell;

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Lung development and regeneration: newly defined cell types and progenitor status

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