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首页> 外文期刊>Mutation Research, C. Mutation Research Letters >INHIBITORY EFFECTS OF COFFEE ON TRANSPLACENTAL GENOTOXICITY IN MICE
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INHIBITORY EFFECTS OF COFFEE ON TRANSPLACENTAL GENOTOXICITY IN MICE

机译：咖啡对小鼠经口基因遗传毒性的抑制作用

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Experiments were carried out to ascertain whether or not coffee can modulate the genotoxicity of transplacentally active genotoxins/carcinogens. Coffee was orally administered to Swiss albino mice (gestation, 15-16 days), 90 min before exposure to cyclophosphamide (CPH), N-nitrosodiethylamine (DEN), N-nitroso-N-ethylurea (ENU) and mitomycin C (MMC). At the end of the treatment, the induction of micronucleated polychromatic erythrocytes (MnPCEs) was evaluated in the fetal liver (FL), fetal blood (FB) and maternal bone marrow (MBM). The results of this transplacental micronucleus test showed a consistent trend which suggests that the administration of coffee instead of water (control) can significantly inhibit the genotoxic effects of CPH, DEW, ENU and MMC in the FL and FB. When the fetal cells were evaluated either 22 and 28 h after CPH treatment, or 24 and 48 h after MMC treatment, there was no evidence for a significant interaction between the sampling time and the inhibitory effect of coffee (two-factor ANOVA). However, a significant interaction was observed between sampling time and the inhibitory effects of coffee when the fetal cells were sampled 24 and 40 h after DEN treatment (two-factor ANOVA). Coffee was also effective in significantly inhibiting the genotoxicity of CPH, ENU and MMC in the MBM. The differential response of fetal and maternal target cells was evident from this study.
机译：进行实验以确定咖啡是否可以调节胎盘活性基因毒素/致癌物的遗传毒性。在暴露于环磷酰胺（CPH），N-亚硝基二乙胺（DEN），N-亚硝基-N-乙基脲（ENU）和丝裂霉素C（MMC）之前90分钟，对瑞士白化病小鼠口服咖啡（妊娠15-16天） 。在治疗结束时，在胎儿肝脏（FL），胎儿血液（FB）和母体骨髓（MBM）中评估了微核多色红细胞（MnPCE）的诱导。经胎盘微核试验的结果显示出一致的趋势，表明用咖啡代替水（对照）可以显着抑制CPH，DEW，ENU和MMC对FL和FB的遗传毒性作用。当在CPH处理后22和28 h或MMC处理后24和48 h评估胎儿细胞时，没有证据表明采样时间与咖啡的抑制作用之间存在显着的相互作用（两因素ANOVA）。但是，当在DEN处理后24和40 h采样胎儿细胞时（两因素ANOVA），采样时间与咖啡的抑制作用之间观察到了显着的相互作用。咖啡还可以有效抑制MBM中CPH，ENU和MMC的遗传毒性。从这项研究中可以明显看出胎儿和母体靶细胞的差异反应。

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