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首页> 外文期刊>Mutation Research, C. Mutation Research Letters >THE RELATIVE RADIOSENSITIVITY OF TK6 AND WI-L2-NS LYMPHOBLASTOID CELLS DERIVED FROM A COMMON SOURCE IS PRIMARILY DETERMINED BY THEIR P53 MUTATIONAL STATUS
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THE RELATIVE RADIOSENSITIVITY OF TK6 AND WI-L2-NS LYMPHOBLASTOID CELLS DERIVED FROM A COMMON SOURCE IS PRIMARILY DETERMINED BY THEIR P53 MUTATIONAL STATUS

机译：来源于共同来源的TK6和WI-L2-NS淋巴母细胞的相对放射敏感性主要由其P53突变状态决定

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摘要

The lymphoblastoid cell lines WI-L2-NS and TK6 were derived from a non-clonal pool of cells taken from a human spleen. Despite their common background they exhibit marked differences in radiosensitivities; D-0 values of 93 and 67 cGy have been reported for WI-L2-NS and TK6 cells respectively. We show here that this differential radiosensitivity is due to a decreased ability of the WI-L2-NS cell line to undergo radiation-induced apoptosis. Further, the WI-L2-NS cell line overexpresses the p53 gene product as a result of a mutation in codon 237 of the p53 gene. These data indicate that WI-L2-NS cells through disruption of normal p53 function are unable to engage the radiation-induced apoptosis program and so are relatively radioresistant.
机译：淋巴母细胞系WI-L2-NS和TK6来源于人类脾脏的非克隆细胞库。尽管具有共同的背景，但它们在放射敏感性方面表现出明显的差异。 WI-L2-NS和TK6细胞的D-0值分别为93和67 cGy。我们在这里显示这种差异的放射敏感性是由于WI-L2-NS细胞系经历辐射诱导的细胞凋亡的能力降低。此外，由于p53基因的密码子237中的突变，WI-L2-NS细胞系过表达p53基因产物。这些数据表明，WI-L2-NS细胞通过破坏正常的p53功能无法参与辐射诱导的凋亡程序，因此具有相对的抗辐射性。

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