A ROLE FOR MISMATCH REPAIR IN PRODUCTION OF CHROMOSOME ABERRATIONS BY METHYLATING AGENTS IN HUMAN CELLS

Galloway SM; Greenwood SK; Hill RB; Bradt CI; Bean CL

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A ROLE FOR MISMATCH REPAIR IN PRODUCTION OF CHROMOSOME ABERRATIONS BY METHYLATING AGENTS IN HUMAN CELLS

机译：通过甲基化试剂在人细胞中修复染色体畸变中的作用

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摘要

We have shown previously that certain alkylation products, or alkylation derived lesions, which induce chromosome aberrations (abs) persist for at least two cell cycles in Chinese hamster ovary cells. The increase in abs in the second cycle after treatment contrasts with the classical observation of reduction in ab yield with successive mitoses following ionizing radiation. Here we present evidence that processing of lesions by mismatch repair is a mechanism for ab induction by methylating agents.

机译：先前我们已经表明，某些引起染色体畸变（abs）的烷基化产物或烷基化衍生的病变在中国仓鼠卵巢细胞中持续至少两个细胞周期。在治疗后第二个周期中，abs的增加与电离辐射后连续有丝分裂的ab产量降低的经典观察结果相反。在这里，我们提供证据表明，通过错配修复对病变进行处理是甲基化剂引起ab诱导的机制。

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《Mutation Research, C. Mutation Research Letters》 |1995年第4期|共15页
作者
Galloway SM; Greenwood SK; Hill RB; Bradt CI; Bean CL;
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正文语种 eng
中图分类遗传学;
关键词
Mismatch repair; Chromosome aberration; Methylating agent; Sister chromatids; Mutations; Homolog; Cancer; Assay; Line;

机译：错配修复;染色体畸变;甲基化剂;姐妹染色单体;突变;同源性;癌症;分析;系;

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专利

1. A role for mismatch repair in production of chromosome aberrations by methylating agents in human cells. [J] . Galloway SM, Greenwood SK, Hill RB, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 1995,第4期

机译：失配修复在人类细胞甲基化剂产生染色体畸变中的作用。
2. Overexpression of N-methylpurine-DNA glycosylase in Chinese hamster ovary cells renders them more sensitive to the production of chromosomal aberrations by methylating agents--a case of imbalanced DNA repair. [J] . Coquerelle T, Dosch J, Kaina B Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 1995,第1期

机译：N-甲基嘌呤-DNA糖基化酶在中国仓鼠卵巢细胞中的过度表达使它们对甲基化剂产生的染色体畸变更加敏感-这是DNA修复失衡的情况。
3. Mutation of the mismatch repair gene hMSH2 and hMSH6 in a human T-cell leukemia line tolerant to methylating agents. [J] . Levati L, Marra G, Lettieri T, Genes, Chromosomes and Cancer . 1998,第2期

机译：在耐受甲基化剂的人T细胞白血病细胞系中错配修复基因hMSH2和hMSH6的突变。
4. PROTON AND IRON (Fe) ION-INDUCED EARLY AND LATE CHROMOSOME ABERRATIONS IN HUMAN EPITHELIAL AND FIBROBLAST CELLS [C] . Rosalin Goss, Honglu Wu, Bobby Wilson, International Astronautical Congress . 2019

机译：质子和铁（Fe）离子诱导人上皮和成纤维细胞中的早期和晚期染色体畸变
5. REJOINING OF X-RAY INDUCED CHROMOSOME BREAKS IN HUMAN CELLS AND ITS RELATIONSHIP TO CELLULAR REPAIR. [D] . CORNFORTH, MICHAEL NORTH. 1985

机译：X射线诱导的人类细胞染色体断裂的恢复及其与细胞修复的关系。
6. Gene Expression Analysis of Tumor Spheroids Reveals a Role for Suppressed DNA Mismatch Repair in Multicellular Resistance to Alkylating Agents [O] . Giulio Francia, Shan Man, Beverly Teicher, 2004

机译：肿瘤球体的基因表达分析揭示了抑制的DNA错配修复在多细胞抗烷基化剂中的作用。
7. Mismatch repair and differential sensitivity of mouse and human cells to methylating agents [O] . O. Humbert 1999

机译：将小鼠和人体细胞的不匹配修复和差异敏感性对甲基化剂
8. Repair in Fertilized Eggs of Mice and Its Role in the Production of Chromosomal Aberrations [R] . Generoso, W. M. 1979

机译：小鼠受精卵的修复及其在染色体畸变生成中的作用

A ROLE FOR MISMATCH REPAIR IN PRODUCTION OF CHROMOSOME ABERRATIONS BY METHYLATING AGENTS IN HUMAN CELLS

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