Thrombotic microangiopathy

Beutel G.; Kielstein J. T.; Ganser A.

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Thrombotic microangiopathy

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abstract_textpThrombotic microangiopathy should be suspected every time the combination of microangiopathic hemolytic anemia without a coexisting cause, thrombocytopenia as well as renal and/or neurologic abnormalities occurs. The general term thrombotic microangiopathy includes different subtypes of the disease leading to abnormalities in multiple organ systems by endothelial injury and formation of platelet-rich thrombi in small vessels. The main types include thrombotic thrombocytopenic purpura in case of dominant neurologic abnormalities and the hemolytic uremic syndrome in case of acute kidney injury, respectively. Although these syndromes differ in their etiologies, clinical features, response to treatment, and prognosis, an early initiation of a direct therapeutic intervention frequently determines the clinical course of the patient. Irrespectively of the underlying etiology, plasma exchange is an essential component of acute therapeutic intervention while ongoing diagnostics are used to identify the definite treatment./p/abstract_text

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《Der Internist》 |2013年第9期|1070-+|共8页
作者
Beutel G.; Kielstein J. T.; Ganser A.;
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作者单位

Hannover Med Sch, Klin Hamatol Hamostaseol Onkol & Stammzelltranspl, D-30625 Hannover, Germany;

Hannover Med Sch, Klin Nieren & Hochdruckerkrankungen, D-30625 Hannover, Germany;

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正文语种英语
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Thrombotic thrombocytopenic purpura; Hemolytic-uremic syndrome; Thrombocytopenia; Microangiopathic hemolytic anemia; Plasma exchange; HEMOLYTIC-UREMIC SYNDROME; VON-WILLEBRAND-FACTOR; THERAPEUTIC PLASMA-EXCHANGE; FACTOR-CLEAVING PROTEASE; THROMBOCYTOPENIC PURPURA; ESCHERICHIA-COLI; ADAMTS13; DEFICIENCY; ERA; METALLOPROTEASE;

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机译：Thrombotic microangiopathy with mild renal involvement and profound thrombocytopenia: not all roads lead to thrombotic thrombocytopenic purpura
2. Indicators Differentiating Thrombotic Thrombocytopenic Purpura From Other Thrombotic Microangiopathies in a Canadian Apheresis Referral Center [J] . Martin Spencer D., McGinnis Eric, Smith Tyler W. American journal of clinical pathology. . 2021,第6期

机译：Indicators Differentiating Thrombotic Thrombocytopenic Purpura From Other Thrombotic Microangiopathies in a Canadian Apheresis Referral Center
3. The long-term consequences of thrombotic microangiopathy (thrombotic thrombocytopenic purpura and hemolytic uremic syndrome) in pregnancy. [J] . Dashe JS, Ramin SM, Cunningham FG Obstetrics and Gynecology: Journal of the American College of Obstetricians and Gynecologists . 1998,第1期

机译：The long-term consequences of thrombotic microangiopathy (thrombotic thrombocytopenic purpura and hemolytic uremic syndrome) in pregnancy.

Thrombotic microangiopathy

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