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首页> 外文期刊>Molecular reproduction and development >Nuclear transfer and cell transplantation: Making more with less
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Nuclear transfer and cell transplantation: Making more with less

机译：核移植和细胞移植：事半功倍

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Pig cloning can be achieved by transfer of nuclei of differentiated somatic cells into enucleated oocytes. Then, developing embryos are placed into surrogate mothers for further development to full term. Although cloned pigs offer the possibility of unlimited organ supply for compatible xenotransplantation in humans, the yield of a predictable number of offspring is stili at an experimental phase. Spermatogonial stem cells from a fertile donor can be transplanted to the testes of infertile recipients and generate sperm. At present, results from xenogeneic spermatogenesis by transplantation indicate that porcine, bovine and equine spermatogonia find the interior of the seminiferous tubular environment not favorable for further differentiation into meiotic prophase spermatocytes, Spermatogenic cell transplantation is a promising experimental alternative for understanding the conditions required by both the donor cells and the recipient testis to coexist and even cooperate towards the full development of fertilizing sperm. Mel. Reprod. Dev. 57:211-213, 2000.
机译：猪的克隆可以通过将分化的体细胞核转移到去核卵母细胞中来实现。然后，将发育中的胚胎置于代孕母亲体内，以进一步发育至足月。尽管克隆的猪为人类兼容的异种移植提供了无限的器官供应的可能性，但是在实验阶段，可预测数量的后代的产量仍然很高。来自可育供体的精原干细胞可以移植到不育受者的睾丸中并产生精子。目前，通过异种精子发生的移植结果表明，猪，牛和马的精原细胞发现生精管状环境的内部不利于进一步分化为减数分裂的前期精子细胞，生精细胞移植是一种有前途的实验性替代方案，可用于了解两者的条件。供体细胞和受体睾丸可以共存，甚至可以共同协作，使受精的精子充分发育。梅尔责备。开发人员57：211-213，2000。

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