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Assessment of risk of adverse events associated with the use of herbal medicines in children with hematological diseases and cancer

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© 2014, Springer-Verlag France.To better assess the prevalence of adverse events (AEs) related to the use of medicinal plants (PM) and inventory the most used in children PM (under 16 years) with hematological diseases and cancer, we conducted a study with 404 patients (or their guardians) for four months at the Pediatric Hematology -Oncology Centre (CHOP) in Rabat. This study was performed using a 10-item questionnaire through which we aim to gather as much information as possible on patients and PM used in hematological diseases and cancer. The survey showed that 14.9 of patients have resorted to the use of PM, all those who have used the PM does not disclose the information to their physician, with a sex ratio of 1.4. Among interviewed patients, using PM, we note that 9.4 had AEs. Analysis of the results showed that tubulo-interstitial nephritis is the most common IE (3.2), followed by cough and cold (0.5), diarrhea (0.2 ) and vomiting (0.2). These results showed that the outcome is favorable in 5 cases. Among the PM used by patients, some of them are involved in adverse reactions, Nigella sativa L. in 5 and Aristolochia longa L. in 2.3. The resort to medicinal plants as an alternative is a major issue for most of patients, herbals are used in first line in 3.9 of the cases, concomitantly in 85 and as a complementary at the end of the medical therapeutic in 11.1. The sensitization of patients, families and physicians is of a major importance for an optimal management of patients.

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