Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction

Patil Pravin; Kurpiewska Katarzyna; Kalinowska-Tluscik JustynaDomling Alexander

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Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction

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Ammonia in the tetrazole Ugi variation together with alpha-amino acid methyl ester-derived isocyanides provides tetrazolopiperidinones in good to high yields in one pot. The scope and limitations of this reaction were investigated by performing >70 reactions. The scaffold is useful to fill high-throughput screening decks and in structure based drug design.

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《ACS combinatorial science》 |2017年第5期|343-350|共8页
作者
Patil Pravin; Kurpiewska Katarzyna; Kalinowska-Tluscik JustynaDomling Alexander;
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作者单位

Jagiellonian Univ, Fac Chem, Dept Crystal Chem & Crystal Phys, Biocrystallog Grp, Ingardena 3, PL-30060 Krakow, Poland;

Univ Groningen, Dept Pharm, Drug Design Grp, Antonius Deusinglaan 1, NL-9713 AV Groningen, Netherlands;

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原文格式 PDF
正文语种英语
中图分类化学;
关键词
tetrazolopiperidinone; isocyanide; multicomponent reaction; Ugi reaction; ammonia Ugi reaction; European Lead Factory;

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Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction

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