One-Pot Synthesis of Densely Substituted Pyrazolo3,4-b-4,7-dihydropyridines

Rao H. Surya Prakash; Adigopula Lakshmi Narayana; Ramadas Krishna

首页> 外文期刊>ACS combinatorial science >One-Pot Synthesis of Densely Substituted Pyrazolo3,4-b-4,7-dihydropyridines

【24h】

One-Pot Synthesis of Densely Substituted Pyrazolo3,4-b-4,7-dihydropyridines

机译：

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

We have achieved a facile synthesis of a combinatorial library of densely substituted pyrazolo3,4-b-4,7-dihydropyridines the mimics of antigenital wart drug podophyllotoxin from 5-aminopyrazoles and 4-(methylthio) 4H-chromenes. The C(4) pyrazolyl 4H-chromenes, which also possess structural features of podophyllotoxin, were isolable intermediates in the two-step, one-pot condensation. The condensation took place in a one-pot, multicomponent manner when 3-oxo-3-phenylpropanenitriles, hydrazine (precursors for 5-aminopyrazoles) and 4-(methylthio)-4H-chromenes were heated in refluxing ethanol. The condensation, however, stops at 4H-chromene stage when methyl hydrazine or phenylhydrazine were employed. Our findings offer an opportunity for synthesis of a combinatorial library of podophyllotoxin mimics, thus paving the way for discovery of lead candidates for cancer treatment.

著录项

来源
《ACS combinatorial science》 |2017年第5期|279-285|共7页
作者
Rao H. Surya Prakash; Adigopula Lakshmi Narayana; Ramadas Krishna;
展开▼
作者单位

Pondicherry Univ, Dept Chem, Pondicherry 605014, India;

Pondicherry Univ, Ctr Bioinformat, Pondicherry 605014, India;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类化学;
关键词
one-pot synthesis; pyrazolo3; 4-b-4; 7-dihydropyridines; podophyllotoxin mimics; combinatorial library; cancer treatment;

相似文献

外文文献
中文文献
专利

1. Expeditious microwavable one-pot synthesis and biological exploration of spiroindoline-3,4 '-pyrazolo3,4-b pyridine derivatives [J] . Naglaa F. H. Mahmoud, Rizk Sameh A., Galal A. ElsayedAli Ali Kh Journal of the Iranian Chemical Society . 2022,第8期

机译：Expeditious microwavable one-pot synthesis and biological exploration of spiroindoline-3,4 '-pyrazolo3,4-b pyridine derivatives
2. ChemInform Abstract: An Efficient Procedure for the Synthesis of 5H‐6‐Substituted‐pyrazolo1,5‐d‐1,2,4‐triazine‐4,7‐diones. [J] . Pier Giovanni Baraldi, Barbara Cacciari, Romeo RomagnoliGiampiero Spalluto Chem Inform . 1999,第27期

机译：ChemInform Abstract: An Efficient Procedure for the Synthesis of 5H‐6‐Substituted‐pyrazolo1,5‐d‐1,2,4‐triazine‐4,7‐diones.
3. ChemInform Abstract: New 2,3‐Substituted 4,7‐Dihydro‐6‐(1′H‐pyrazol‐3′‐yl)pyrazolo(1,5‐a) pyrimidin‐7‐ones and Related Compounds: Synthesis and Benzodiazepine Receptor Binding Study. [J] . S. SELLERI, F. BRUNI, A. COSTANZOG. GUERRINIM. L. CASILLIL. GIUSTIA. LUCACCHINIC. MARTINI Chem Inform . 1996,第18期

机译：ChemInform Abstract: New 2,3‐Substituted 4,7‐Dihydro‐6‐(1′H‐pyrazol‐3′‐yl)pyrazolo(1,5‐a) pyrimidin‐7‐ones and Related Compounds: Synthesis and Benzodiazepine Receptor Binding Study.
4. Organic Photovoltaic Cells of Fully Conjugated Poly 2,6- (4,4-bis(2-ethylhexyl)-4H-cyclopenta2,1-b;3,4-b'dithiophene)-alt-4, 7-(2,1,3-benzothiadiazole) Doped with Fullerene [C] . Jen Wei Huang, Ming Seng Hsu, Tzu-Chin Lin Photonic fiber and crystal devices: advances in materials and innovations in device applications VIII . 2014

机译：完全共轭的聚2,6-（4,4-双（2-乙基己基）-4H-环戊2,1-b; 3,4-b'二噻吩）-alt-4，7-的有机光伏电池（2,1,3-苯并噻二唑）富勒烯掺杂
5. Tuning the Solubility of Copper Complex in Atom Transfer Radical Self-Condensing Vinyl Polymerizations to Control Polymer Topology via One-Pot to the Synthesis of Hyperbranched Core Star Polymers [O] . Chen Zong-Cheng, Chiu Chia-Ling, Huang Chih-Feng 2015

机译：Tuning the solubility of Copper Complex in atom Transfer Radical self-Condensing Vinyl polymerizations to Control polymer Topology via One-pot to the synthesis of Hyperbranched Core star polymers

One-Pot Synthesis of Densely Substituted Pyrazolo3,4-b-4,7-dihydropyridines

摘要

著录项

相似文献

相关主题

期刊订阅