Noise analysis and reduction in solid-state nanopores

Tabard-Cossa V; Trivedi D; Wiggin M; Jetha NN; Marziali A

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Noise analysis and reduction in solid-state nanopores

机译：固体纳米孔的噪声分析和减少

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The electrical noise characteristics of ionic current through organic and synthetic nanopores have been investigated. Comparison to proteinaceous alpha-Hemolysin pores reveals two dominant noise sources in silicon nitride nanometre-scale pores: a high-frequency noise associated with the capacitance of the silicon support chip (dielectric noise), and a low- frequency current fluctuation with 1/f (alpha) characteristics (flicker noise). We present a technique for reducing the dielectric noise by curing polydimethylsiloxane (PDMS) on the nanopore support chip. This greatly improves the performance of solid-state nanopore devices, yielding an unprecedented signal-to-noise ratio when observing dsDNA translocation events and ssDNA probe capture for force spectroscopy applications.

机译：已经研究了通过有机和合成纳米孔的离子电流的电噪声特性。与蛋白质的α-溶血素孔比较，发现氮化硅纳米级孔中的两个主要噪声源：与硅支撑芯片的电容相关的高频噪声（介电噪声）和1 / f的低频电流波动α特性（闪烁噪声）。我们提出了一种通过固化纳米孔支撑芯片上的聚二甲基硅氧烷（PDMS）来降低介电噪声的技术。这大大提高了固态纳米孔器件的性能，在观察dsDNA易位事件和用于力谱应用的ssDNA探针捕获时，产生了空前的信噪比。

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《Nanotechnology》 |2007年第30期|共6页
作者
Tabard-Cossa V; Trivedi D; Wiggin M; Jetha NN; Marziali A;
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正文语种 eng
中图分类一般工业技术;
关键词
SELF-ORGANIZED CRITICALITY; 1/F NOISE; ELECTRON-BEAM; DNA TRANSLOCATION; POLYNUCLEOTIDE MOLECULES; SEQUENCING TECHNOLOGY; FABRICATED NANOPORES; FLICKER NOISE; CHANNEL; TRANSPORT;

机译：自组织临界度;1 / F噪声;电子束;DNA转运;多核苷酸分子;测序技术;制备的纳米孔;闪烁噪声;通道;运输;

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专利

1. Noise analysis and reduction in solid-state nanopores [J] . Vincent Tabard-Cossa, Dhruti Trivedi, Matthew Wiggin Nanotechnology . 2007,第30期

机译：固体纳米孔的噪声分析和减少
2. Integrated solid-state nanopore platform for nanopore fabrication via dielectric breakdown, DNA-speed deceleration and noise reduction [J] . Yusuke Goto, Itaru Yanagi, Kazuma Matsui, Scientific reports. . 2016,第1期

机译：集成的固态纳米孔平台，可通过电介质击穿，DNA速度减速和降噪来制造纳米孔
3. Noise Spectroscopy Analysis for Estimation of a Specific Biomolecule in a Complex Mixture Using Solid-State Nanopore [J] . Naren Das, Nirmalya Samanta, Aneesh M. Joseph, IEEE transactions on nanotechnology . 2018,第6期

机译：使用固态纳米孔估计复杂混合物中特定生物分子的噪声光谱分析
4. Low-frequency noise reduction with solid-state nanopores by preventing surface charge fluctuation [C] . Kazuma Matsui, Yusuke Goto, Rena Akahori, 応用物理学会秋季学術講演会;応用物理学会 . 2018

机译：通过防止表面电荷波动，利用固态纳米孔降低低频噪声
5. Precise size control and noise reduction of solid-state nanopores for the detection of DNA-protein complexes [D] . Beamish, Eric 2012

机译：用于检测DNA蛋白复合物的固态纳米孔的精确尺寸控制和降噪
6. Integrated solid-state nanopore platform for nanopore fabrication via dielectric breakdown DNA-speed deceleration and noise reduction [O] . Yusuke Goto, Itaru Yanagi, Kazuma Matsui, -1

机译：集成的固态纳米孔平台可通过介电击穿DNA速度减速和降噪来制造纳米孔
7. Integrated solid-state nanopore platform for nanopore fabrication via dielectric breakdown, DNA-speed deceleration and noise reduction [O] . Yusuke Goto, Itaru Yanagi, Kazuma Matsui, 2016

机译：通过介电击穿，DNA速度减速和降噪纳米孔制造的集成固态纳米孔平台

Noise analysis and reduction in solid-state nanopores

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