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Vertically aligned carbon nanotube probes for monitoring blood cholesterol

机译：垂直排列的碳纳米管探针，用于监测血液胆固醇

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摘要

Detection of blood cholesterol is of great clinical significance. The amperometric detection technique was used for the enzymatic assay of total cholesterol. Multiwall carbon nanotubes (MWNTs), vertically aligned on a silicon platform, promote heterogeneous electron transfer between the enzyme and the working electrode. Surface modification of the MWNT with a biocompatible polymer, polyvinyl alcohol (PVA), converted the hydrophobic nanotube surface into a highly hydrophilic one, which facilitates efficient attachment of biomolecules. The fabricated working electrodes showed a linear relationship between cholesterol concentration and the output signal. The efficacy of the multiwall carbon nanotubes in promoting heterogeneous electron transfer was evident by distinct electrochemical peaks and higher signal-to-noise ratio as compared to the Au electrode with identical enzyme immobilization protocol. The selectivity of the cholesterol sensor in the presence of common interferents present in human blood, e.g. uric acid, ascorbic acid and glucose, is also reported.
机译：血液中胆固醇的检测具有重要的临床意义。安培检测技术用于总胆固醇的酶促测定。在硅平台上垂直排列的多壁碳纳米管（MWNT）促进了酶和工作电极之间的异质电子转移。用生物相容性聚合物聚乙烯醇（PVA）对MWNT进行表面改性，将疏水性纳米管表面转变为高度亲水的表面，从而促进生物分子的有效附着。制成的工作电极在胆固醇浓度和输出信号之间显示出线性关系。与具有相同酶固定方案的Au电极相比，多壁碳纳米管在促进异质电子转移方面的功效通过明显的电化学峰和更高的信噪比得到了证明。在人血中存在常见干扰物时，胆固醇传感器的选择性还报道了尿酸，抗坏血酸和葡萄糖。

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