CD95: more than just a death factor? (news)

Hueber AO

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CD95: more than just a death factor? (news)

机译：CD95：不仅仅是死亡因素？（新闻）

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The CD95 protein delivers crucial signals for lymphocyte death, and may also negatively regulate T-lymphocyte activation by preventing the influx of calcium ions from the cell's exterior. The block in calcium-ion influx occurs through the activation of acidic sphingomyelinase and the release of ceramide, a metabolite that can also induce cell death.

机译：CD95蛋白可为淋巴细胞死亡提供关键信号，并可能通过阻止钙离子从细胞外部流入而负面调节T淋巴细胞的活化。钙离子流入的阻滞通过酸性鞘磷脂酶的活化和神经酰胺的释放而发生，神经酰胺是一种也可以诱导细胞死亡的代谢产物。

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《Nature cell biology》 |2000年第2期|共9页
作者
Hueber AO;
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正文语种 eng
中图分类细胞生物学;
关键词
Antigens; CD95; Cell Death; Lymphocyte Transformation; Receptors; Antigen; T-Cell; 抗原; CD95; 细胞死亡; 淋巴细胞转化; 受体; 抗原; T细胞; T淋巴细胞;

机译：Antigens;CD95;Cell Death;Lymphocyte Transformation;Receptors;Antigen;T-Cell;抗原;CD95;细胞死亡;淋巴细胞转化;受体;抗原;T细胞;T淋巴细胞;

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1. T-cell factor (TCF/LEF1) binding elements (TBEs) of FasL (Fas ligand or CD95 ligand) bind and cluster Fas (CD95) and form complexes with the TCF-4 and b-catenin transcription factors in vitro and in vivo which result in triggering cell death and/or cell activation [J] . Liu Xia, Huang Yuwei, Zhang Yuanyuan, Cellular and Molecular Neurobiology . 2016,第6期

机译：FasL（Fas配体或CD95配体）的T细胞因子（TCF / LEF1）结合元件（TBEs）在体外和体内与Fas（CD95）结合并成簇，并与TCF-4和b-catenin转录因子形成复合物，导致触发细胞死亡和/或细胞活化
2. Viral IFN-Regulatory Factors Inhibit Activation-Induced Cell Death Via Two Positive Regulatory IFN-Regulatory Factor 1-Dependent Domains in the CD95 Ligand promoter [J] . Sabine Kirchhoff, Thorsten Sebens, Sven Baumann, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2002,第3期

机译：病毒IFN调节因子通过CD95配体启动子中的两个正调节IFN调节因子1依赖域抑制激活诱导的细胞死亡。
3. Viral IFN-Regulatory Factors Inhibit Activation-Induced Cell Death Via Two Positive Regulatory IFN-Regulatory Factor 1-Dependent Domains in the CD95 Ligand Promoter [J] . Sabine Kirchhoff, Thorsten Sebens, Sven Baumann, The journal of immunology . 2002,第3期

机译：病毒IFN调节因子通过CD95配体启动子中的两个正调节IFN调节因子1依赖域抑制激活诱导的细胞死亡。
4. Quantification of the CD95 death inducing signaling complex (CD95-DISC) proteins comparing Orbitrap and QTrap MS data [C] . Uwe Warnken, Kerstin Kammerer, Sebastian Link, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：定量CD95死亡诱导信号络合物（CD95-盘）蛋白质比较orbitrap和Qtrap MS数据的蛋白质
5. Roles of cellular FLICE-inhibitory protein (c-FLIP) and PI3K/Akt in Fas (CD95)-induced NF-kappaB activation and apoptosis through death effector domains. [D] . Lu, Bin. 2005

机译：细胞FLICE抑制蛋白（c-FLIP）和PI3K / Akt在Fas（CD95）诱导的NF-κB活化和细胞凋亡中通过死亡效应域的作用。
6. CD95 ligand - death factor and costimulatory molecule? [O] . O Janssen, J Qian, A Linkermann, -1

机译：CD95配体-死亡因子和共刺激分子？
7. High expression of CD40 on B-cell precursor acute lymphoblastic leukemia blasts is an independent risk factor associated with improved survival and enhanced capacity to up-regulate the death receptor CD95 [O] . Troeger A. (Anja), Glouchkova L. (Ludmila), Ackermann B. (Birgit), 2008

机译：CD40在B细胞前体急性淋巴细胞白血病胚细胞中的高表达是与生存率提高和上调死亡受体CD95的能力增强相关的独立危险因素

CD95: more than just a death factor? (news)

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