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Cancer metabolism

机译：癌症新陈代谢

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摘要

This special collection presents a selection of recent papers published in Nature and Nature Reviews Cancer that highlight the burgeoning interest in cancer metabolism. That cancers display an altered cellular metabolism was first recognized almost a century ago, notably in Otto Warburg's description of a switch in glucose metabolism from oxidative phosphorylation to glycolysis - the Warburg effect. However, as described in the Review by Tak W. Mak and colleagues on page 5, only recently have links been established between the oncogenic pathways that drive tumorigenesis and the mechanistic basis of tumour cell metabolism. A picture is now emerging showing that cancer-related genes, such as MYC (the subject of a paper on page 42) and isocitrate dehydrogenase 1 (IDH1; some of the effects of the R132H mutation are presented on page 38), have substantial effects on cancer cell metabolism.
机译：该特别收藏提供了一系列精选的近期发表在《自然》和《自然评论癌症》上的论文，这些论文突出了人们对癌症代谢的新兴兴趣。癌症显示出细胞代谢发生改变是近一个世纪前首次发现的，尤其是在奥托·沃伯格（Otto Warburg）对葡萄糖代谢从氧化磷酸化转变为糖酵解的转变的描述中-沃伯格效应。但是，正如Tak W. Mak及其同事在第5页的评论中所述，直到最近才在驱动肿瘤发生的致癌途径与肿瘤细胞代谢的机制基础之间建立了联系。现在出现了一张图片，显示与癌症相关的基因，例如MYC（第42页上的论文主题）和异柠檬酸脱氢酶1（IDH1; R132H突变的某些作用列于第38页）具有实质性作用对癌细胞的新陈代谢。

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