Crystal structure of Brinzolamide: a carbonic anhydrase inhibitor

Zheng H.; Lou B.

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Crystal structure of Brinzolamide: a carbonic anhydrase inhibitor

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In crystal structure of the title compound, C12H21N3O5S3 systematic name: (R)-4-ethyl#173;amino-2-(3-meth#173;oxy#173;prop#173;yl)-3,4-di#173;hydro-2H-thieno3,2-e1,2thia#173;zine-6-sulfonamide 1,1-dioxide, there exist three kinds of hydrogen-bonding inter#173;actions. The sulfonamide group is involved in hydrogen bonding with the secondary amine and the meth#173;oxy O atom, resulting in the formation of layers parallel to the bc plane. The layers are linked by an N#8212;H#8943;O hydrogen bond involving a sulfonamide O atom as acceptor and the secondary amine H atom as donor, which gives rise to the formation of a unique bilayer structure. The absolute structure of the mol#173;ecule in the crystal was determined by resonant scattering Flack parameter = 0.01#8197;(4).

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《Acta Crystallographica Section E: Crystallographic Communications》 |2016年第5期|692-695|共4页
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Zheng H.; Lou B.;
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Crystal structure of Brinzolamide: a carbonic anhydrase inhibitor

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