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首页> 外文期刊>Nature immunology >Foxp1 is an essential transcriptional regulator of B cell development
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Foxp1 is an essential transcriptional regulator of B cell development

机译：Foxp1是B细胞发育必不可少的转录调节因子

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摘要

Forkhead transcription factors are key participants in development and immune regulation. Here we demonstrate that absence of the gene encoding the forkhead transcription factor Foxp1 resulted in a profound defect in early B cell development. Foxp1 deficiency was associated with decreased expression of all B lineage genes in B220(+) fetal liver cells as well as with a block in the transition from pro-B cell to pre-B cell involving diminished expression of recombination-activating genes 1 and 2. Foxp1 bound to the Erag enhancer and was involved in controlling variable-(diversity)-joining recombination of the gene encoding immunoglobulin heavy chain in a B cell lineage - specific way. Our results identify Foxp1 as an essential participant in the transcriptional regulatory network of B lymphopoiesis.
机译：额头转录因子是发育和免疫调节的主要参与者。在这里，我们证明了缺乏编码叉头转录因子Foxp1的基因导致早期B细胞发育的严重缺陷。 Foxp1缺乏症与胎儿B220（+）肝细胞中所有B谱系基因的表达降低以及从前B细胞到前B细胞的转变受阻有关，涉及重组激活基因1和2的表达减少。 Foxp1结合到Erag增强子上，并参与以B细胞谱系特异性的方式控制编码免疫球蛋白重链的基因的可变（多样性）结合重组。我们的结果确定Foxp1是B淋巴细胞生成的转录调控网络的重要参与者。

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