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Body-barrier surveillance by epidermal γδ TCRs

机译：表皮γδTCRs监测人体屏障

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The surveillance of body barriers relies on resident T cells whose repertoires are biased toward particular γδ T cell antigen receptors (TCRs) according to location. These γδ TCRs can recognize ligands that emerge after stress. Through the use of intravital dynamics-immunosignal correlative microscopy, we found that γ-chain variable region 5 (V γ 5) TCRs expressed by epidermal T cells were constitutively clustered and functionally activated in vivo at steady state, forming true immunological synapses that polarized and anchored T cell projections at squamous keratinocyte tight junctions. This synaptogenesis depended on TCR variable domains, the kinase Lck and the integrin α E β 7 but not the γδ lineage or the receptor NKG2D. In response to tissue stress, TCR-proximal signals did not increase substantially but underwent stress mode-dependent relocalization toward the basal epidermis and Langerhans cells. Thus, the γδ TCR orchestrates barrier surveillance proactively, presumably by recognizing tissue ligands expressed in the steady state.
机译：对身体屏障的监视依赖于驻留的T细胞，这些T细胞的组成根据位置偏向特定的γδT细胞抗原受体（TCR）。这些γδTCR可以识别应力后出现的配体。通过使用活体内动力学-免疫信号相关显微镜技术，我们发现表皮T细胞表达的γ链可变区5（Vγ5）TCR在体内处于稳态状态下组成性聚集并功能性激活，形成了极化和极化的真实免疫突触。在鳞状角质形成细胞紧密连接处锚定T细胞投射。这种突触发生依赖于TCR可变域，激酶Lck和整联蛋白αEβ7，而不是γδ谱系或受体NKG2D。响应组织压力，TCR近端信号并未显着增加，但经历了应力模式依赖的向基底表皮和朗格汉斯细胞的重新定位。因此，γδTCR可能通过识别以稳定状态表达的组织配体来主动协调屏障监视。

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