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Can DCs be distinguished from macrophages by molecular signatures?

机译:DC是否可以通过分子特征与巨噬细胞区分开?

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To the Editor: An article from the Immunological Genome (ImmGen) Consortium published in Nature Immunology focuses on the differentiation of dendritic cells (DCs) in the mouse and efforts to distinguish those cells from macrophages. In that article, Miller et al. report a small set of markers whose expression is restricted to or shows higher expression in DCs relative to their expression in four prototypical tissue macrophage populations1. Those findings contrast to our own observations obtained with large microarray data sets of macrophages and DCs, and we wish to provide a different perspective.
机译:致编辑:发表于《自然免疫学》上的免疫基因组(ImmGen)联盟的一篇文章着重于小鼠中树突状细胞(DC)的分化以及努力将这些细胞与巨噬细胞区分开。在那篇文章中,Miller等人。报告了一组标记,相对于四个典型组织巨噬细胞群体中的表达,其表达受限于DC或在DC中显示较高的表达1。这些发现与我们从巨噬细胞和DC的大型微阵列数据集获得的观察结果形成对比,我们希望提供不同的观点。

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