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首页> 外文期刊>Nature immunology >Interferon with dendritic cells?
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Interferon with dendritic cells?

机译：干扰素与树突状细胞？

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Rapid production of type I interferon (IFN-α/β) is a characteristic response to many infections. IFN-α/β lays a key role in limiting early viral spread by inducing the expression of numerous genes that interfere with viral replication and by activating natural killer (NK) cells and macrophages to kill infected cells. Although most cell types are capable of expressing IFN-α/β, the capacity to secrete high amounts of type I IFN appears to be restricted to relatively rare cells. Several years ago, unusual cells were identified in human blood that secreted high amounts of IFN-α/β, expressed low amounts of cell surface CD4 and major histocompatibility complex (MHC) class II, but lacked hematopioetic-lineage markers. These cells were recently shown to correspond to a population of cells with plasmacytoid morphology that are present in the T cell areas of inflamed lymph nodes and are capable of differentiating into dendritic cells (DCs). As reported by Asselin-Paturel et al. in this issue of Nature Immunology and by Nakano et al. in the Journal of Experimental Medicine, it is now clear that an analogous plasmacytoid cell population that secretes high amounts of IFN-α/β also exists in the mouse.
机译：I型干扰素（IFN-α/β）的快速生产是对许多感染的特征性反应。 IFN-α/β通过诱导众多干扰病毒复制的基因表达并激活自然杀伤（NK）细胞和巨噬细胞以杀死受感染的细胞，在限制早期病毒扩散中发挥关键作用。尽管大多数细胞类型都能够表达IFN-α/β，但分泌大量I型IFN的能力似乎仅限于相对罕见的细胞。几年前，在人类血液中发现了异常细胞，它们分泌大量的IFN-α/β，表达少量的细胞表面CD4和II类主要组织相容性复合物（MHC），但缺乏造血谱系标记物。最近显示，这些细胞对应于浆细胞样形态的细胞群，这些细胞群存在于发炎的淋巴结的T细胞区域，能够分化为树突状细胞（DC）。如Asselin-Paturel等报道。在Nakano等人的《自然免疫学》（Nature Immunology）一书中。在《实验医学杂志》中，现在清楚的是，小鼠中还存在分泌大量IFN-α/β的类似浆细胞样细胞群。

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