...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature immunology >POP goes the inflammasome
【24h】

POP goes the inflammasome

机译：POP发炎

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Encoded in the human genome are dozens (probably hundreds) of receptors that detect a wide range of molecular motifs derived from pathogens or from damaged host tissue, collectively called 'pattern-recognition receptors' (PRRs). As part of the innate immune response, the triggering of specific PRRs orchestrates a swift inflammatory response that includes alterations in cellular transcriptional programs, the release of cytokines and even cell death. However, the robust immune response that ensues can lead to the collateral damage of host tissues. Therefore, numerous molecules also exist that limit the activity of PRRs once triggered. In this issue of Nature Immunology, Khare et al. identify one such regulator, POP3, as a previously unknown member of a family of inhibitors of PRRs that is important in regulating the response to double-stranded DNA (dsDNA)1.There are many cytoplasmic sensors of nucleic acids that detect invading viruses and bacteria2. AIM2 ('absent in melanoma 2') and its closely related family member IFI16 are two such sensors and are members of the DNA-binding PYHIN ('PYRIN and HIN-200 domain-containing') family. The PYHIN family (or, in keeping with the dominant nomenclature in the PRR field, the 'AIM2-like receptor' (ALR) family) has 4 members in humans and 13 predicted members in mice. AIM2 directly binds to long stretches of cytosolic dsDNA regardless of its sequence.
机译：在人类基因组中编码的是数十种（可能是数百种）受体，这些受体检测从病原体或受损宿主组织衍生的各种分子基序，统称为“模式识别受体”（PRR）。作为先天性免疫反应的一部分，特定PRR的触发可安排迅速的炎症反应，包括细胞转录程序的改变，细胞因子的释放甚至细胞死亡。但是，随后发生的强大免疫反应可能导致宿主组织的附带损害。因此，一旦触发，也存在许多限制PRR活性的分子。在本期《自然免疫学》中，Khare等人。确定一种这样的调节剂POP3作为PRR抑制剂家族中一个未知的成员，该家族在调节对双链DNA（dsDNA）1的反应中起着重要的作用。核酸中的许多细胞质传感器可检测到入侵的病毒和细菌2 。 AIM2（“黑色素瘤2缺失”）及其密切相关的家族成员IFI16就是两个这样的传感器，并且是DNA结合PYHIN（“含PYRIN和HIN-200结构域”）家族的成员。 PYHIN家族（或与PRR领域的主要命名法一致，“ AIM2样受体”（ALR）家族）在人类中有4个成员，在小鼠中有13个预测成员。无论其序列如何，AIM2均可直接与长链胞质dsDNA结合。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号