Universal influenza virus vaccines: Need for clinical trials

KrammerF.; PaleseP.

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Universal influenza virus vaccines: Need for clinical trials

机译：通用流感病毒疫苗：需要临床试验

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Vaccines are currently the best counter-measure against influenza virus infections in humans. However, available vaccines are limited in breadth such that they are effective against only the circulating strains that are closely related to the vaccine strain. The genetic variation of influenza viruses allows them to escape immune responses quickly, a mechanism called antigenic drift. Therefore, influenza vaccination programs require annual revaccination with reformulated vaccines-a cumbersome and expensive undertaking. Because vaccine strain selection is based on surveillance and prediction, mismatches between vaccine strains and circulating viruses occur, resulting in a sharp drop of vaccine efficacy.

机译：疫苗是目前针对人类流感病毒感染的最佳对策。然而，可用疫苗的广度受到限制，使得它们仅对与该疫苗株密切相关的循环株有效。流感病毒的遗传变异使它们能够快速逃避免疫反应，这种机制称为抗原漂移。因此，流感疫苗接种计划需要每年重新配制的疫苗，这既繁琐又昂贵。由于疫苗株的选择基于监视和预测，因此会在疫苗株和正在传播的病毒之间发生不匹配，从而导致疫苗效力急剧下降。

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《Nature immunology》 |2014年第1期|共3页
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KrammerF.; PaleseP.;
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正文语种 eng
中图分类医学免疫学;
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机译：迈向禽流感通用疫苗：经修饰的痘苗病毒安卡拉和腺病毒疫苗在低致病性禽流感病毒攻击的鸡中表达保守流感抗原的保护作用
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Universal influenza virus vaccines: Need for clinical trials

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