Two ortho#173;rhom#173;bic polymorphs of hydro#173;morphone

Mazurek J.; Hoffmann M.; Fernandez Casares A.Cox D.P.Minardi M.D.Sasine J.

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Two ortho#173;rhom#173;bic polymorphs of hydro#173;morphone

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Conditions to obtain two polymorphic forms by crystallization from solution were determined for the analgesic drug hydro#173;morphone C17H19NO3; systematic name: (4R,4aR,7aR,12bS)-9-hy#173;droxy-3-methyl-1,2,4,4a,5,6,7a,13-octa#173;hydro-4,12-methano#173;benzofuro3,2-eiso#173;quinolin-7-one. These two crystalline forms, designated as I and II, belong to the P212121 ortho#173;rhom#173;bic space group. In both polymorphs, the hydro#173;morphone mol#173;ecules adopt very similar conformations with some small differences observed only in the N-methyl amine part of the mol#173;ecule. The crystal structures of both polymorphs feature chains of mol#173;ecules connected by hydrogen bonds; however, in form I this inter#173;action occurs between the hydroxyl group and the tertiary amine N atom whereas in form II the hydroxyl group acts as a donor of a hydrogen bond to the O atom from the cyclic ether part.

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《Acta Crystallographica Section E: Crystallographic Communications》 |2016年第5期|730-733|共4页
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Mazurek J.; Hoffmann M.; Fernandez Casares A.Cox D.P.Minardi M.D.Sasine J.;
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Two ortho#173;rhom#173;bic polymorphs of hydro#173;morphone

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