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首页> 外文期刊>Nature reviews. Urology >Novel biomarkers for overactive bladder.
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Novel biomarkers for overactive bladder.

机译：膀胱过度活动症的新型生物标志物。

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摘要

Biomarkers constitute any objectively measurable indicator of a biological process. The classic biomarker used in the diagnosis of overactive bladder (OAB) has been detrusor overactivity, which is assessed urodynamically. In the search for a reliable, noninvasive alternative to urodynamics, interest has focused on genetic, imaging, and urinary factors. Along with other cytokines detectable in urine, prostaglandin E2 and nerve growth factor are indicators of low-grade inflammation. Although they correlate with OAB symptom severity, they have not been shown to have independent prognostic benefit. Imaging biomarkers have been investigated since the earliest days of video urodynamics. Despite extensive research on the ultrasonographic estimation of bladder wall thickness, further standardization of the technique is required before conclusions can be reached regarding diagnostic accuracy. Genetic factors contribute approximately half of the total risk for urgency incontinence. Functional polymorphisms of the cytochrome P450 IID6 gene significantly alter the metabolism of some commonly used anticholinergic drugs, but no genetic loci that influence risk of OAB have been definitively identified. The first genome-wide association studies for OAB are in progress, and should identify new susceptibility genes. Although current putative biomarkers correlate with OAB severity, much future work is required to assess their prognostic value, and establish their role in clinical practice.
机译：生物标志物是生物学过程中任何可客观测量的指标。诊断膀胱过度活动症（OAB）的经典生物标志物是逼尿肌过度活动，可通过尿动力学进行评估。在寻找一种可靠的，无创的尿动力学替代方法时，人们的兴趣集中在遗传，影像学和泌尿方面。与尿液中可检测到的其他细胞因子一起，前列腺素E2和神经生长因子是低度炎症的指标。尽管它们与OAB症状严重程度相关，但尚未显示它们具有独立的预后益处。自视频尿动力学开始以来，就已经研究了成像生物标志物。尽管对膀胱壁厚度的超声检查进行了广泛的研究，但在就诊断准确性得出结论之前，仍需要对该技术进行进一步的标准化。遗传因素约占尿失禁总数的一半。细胞色素P450 IID6基因的功能多态性显着改变了一些常用的抗胆碱能药物的代谢，但尚未明确鉴定出影响OAB风险的遗传基因座。 OAB的第一个全基因组关联研究正在进行中，应该确定新的易感基因。尽管当前推测的生物标志物与OAB严重程度相关，但仍需要大量未来工作来评估其预后价值，并确立其在临床实践中的作用。

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