Acute Rejection Correlates with Expression of Major Histocompatibility Complex Class I Antigens on Peripheral Blood CD3(+)CD8(+) T-Lymphocytes following Skin Transplantation in Mice.

Zhou YX; Zhao SM; Lu NYang XJZhang YLi YJZou X

首页> 外文期刊>The Journal of international medical research >Acute Rejection Correlates with Expression of Major Histocompatibility Complex Class I Antigens on Peripheral Blood CD3(+)CD8(+) T-Lymphocytes following Skin Transplantation in Mice.

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Acute Rejection Correlates with Expression of Major Histocompatibility Complex Class I Antigens on Peripheral Blood CD3(+)CD8(+) T-Lymphocytes following Skin Transplantation in Mice.

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This study investigated major histocompatibility complex class I (MHC-I) antigen expression on peripheral blood T-cells after transplantation to assess its potential as an early marker of acute graft rejection (AGR). Using a mouse model with or without immunosuppressive treatment, the expression of MHC-I antigens on CD3(+)CD8(+) T-lymphocytes was assessed by flow cytometry following syngeneic graft (n = 138) or allograft (n = 138) skin transplantation. The occurrence of AGR was assessed by examining the degree of lymphocyte and monocyte infiltration in transplant biopsies. During AGR, expression of MHC-I antigens increased significantly compared with pre-transplant levels in the allograft group, even with immunosuppressive treatment. The highest expression of MHC-I antigens occurred 5 - 6 days before macroscopic rejection. These results suggest that expression of MHC-I antigens on peripheral blood CD3(+)CD8(+) T-lymphocytes could be used as an early marker for predicting AGR.

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《The Journal of international medical research》 |2011年第2期|480-487|共8页
作者
Zhou YX; Zhao SM; Lu NYang XJZhang YLi YJZou X;
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Clinical Laboratory Department, Maternity Hospital, Shandong Provincial Hospital, Shandong University, Jinan, China.;

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正文语种英语
中图分类医药、卫生;
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1. Major histocompatibility complex class II antigen (HLA‐DR, DQ and DP) expression in human fetal skin [J] . H. F. Sewell, A. W. Thomson, F. WalkerG. KingD. R. Abramovich tissue antigens . 1986,第1期

机译：Major histocompatibility complex class II antigen (HLA‐DR, DQ and DP) expression in human fetal skin
2. Fine-Needle Aspiration Biopsy Sampling in Renal Transplantation: Interstitial Cellular Infiltrates and Major Histocompatibility Complex Class-II Antigen Expression in Renal Tubular Cells [J] . Stephan M. Miller, Philip Belitsky, Rekha Gupta urologia internationalis . 1989,第6期

机译：Fine-Needle Aspiration Biopsy Sampling in Renal Transplantation: Interstitial Cellular Infiltrates and Major Histocompatibility Complex Class-II Antigen Expression in Renal Tubular Cells
3. Analysis of immunological tolerance to major histocompatibility complex antigens. I. High frequencies of tolerogen‐specific cytotoxic T lymphocyte precursors in mice neonatally tolerized to class I major histocompatibility complex antigens [J] . Klaus Heeg, Hermann Wagner european journal of immunology . 1985,第1期

机译：Analysis of immunological tolerance to major histocompatibility complex antigens. I. High frequencies of tolerogen‐specific cytotoxic T lymphocyte precursors in mice neonatally tolerized to class I major histocompatibility complex antigens

Acute Rejection Correlates with Expression of Major Histocompatibility Complex Class I Antigens on Peripheral Blood CD3(+)CD8(+) T-Lymphocytes following Skin Transplantation in Mice.

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