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Impact of Taiwan’s 2021 COVID-19 lockdown on the symptom severity and quality of life of patients with narcolepsy

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Abstract COVID-19 lockdowns can influence the sleep quality and daytime condition of patients with narcolepsy. Using data from our cohort study, we investigated changes in the quality of life and the symptom severity of patients with narcolepsy during Taiwan’s 2021 lockdown and investigated differences by narcolepsy subtype, sex, and age. Patients with type 1 and type 2 narcolepsy (NT1 and NT2, respectively) aged 6–40?years were retrospectively recruited from our narcolepsy cohort study. These patients were regularly evaluated using the Short Form 36 Health Survey questionnaire (SF-36), the Epworth Sleepiness Scale (ESS), the visual analog scale (VAS) for hypersomnolence, the VAS for cataplexy and sleep diary. We compared the differences between the lockdown and the prelockdown periods by narcolepsy subtype, sex, and age. We used a paired t test analysis to compare differences in the SF-36, ESS, VAS scores and data of sleep diary between the prelockdown and lockdown periods (p1), and an independent t test analysis was used to compare the changes in different subgroups between the prelockdown and lockdown periods (p2). A total of 120 patients with narcolepsy were recruited (mean age 24.22?±?6.87?years; 58 male); 80 of the patients had NT1 (mean age 25.25?±?6.79?years; 60 male) and 40 had NT2 (mean age 22.16?±?6.64, 53 male). During the lockdown period, the ESS score of total patients was decreased (p?=?0.039) and body mass index was increased (p?=?0.02). The NT1 group decreased significantly (p1?=?0.017), especially in men (p1?=?0.016) and adults (p1?=?0.04); scores for the VT domain of the SF-36 increased significantly in male and adult patients with NT2 (p1?=?0.048 and 0.012). Additionally, male patients with NT2 exhibited significantly decreased scores in the physical and emotional role functioning domains (p1?=?0.028, 0.024). The children and adolescents with NT1 had significantly decreased scores in the general health domain of the SF-36, but no significant change was noted in that of adults (p1?=?0.027, p2?=?0.012). We observed both negative and positive impacts of Taiwan’s 2021 lockdown on patients with narcolepsy. A more flexible but structured daily routine with adequate sleep time should be considered for this population during lockdown and nonlockdown periods.

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