...
首页> 外文期刊>Neuron >Taking two TRAILS.
【24h】

Taking two TRAILS.

机译:采取两条轨迹。

获取原文
获取原文并翻译 | 示例
           

摘要

The TNF-related apoptosis-inducing ligand (TRAIL) has well-described anti-inflammatory effects in models of autoimmune disease, including experimental autoimmune encephalomyelitis (EAE). In this issue of Neuron, Aktas, Smorodchenko, and colleagues present evidence that TRAIL exerts anti-inflammatory effects, but also induces neuronal apoptosis, in EAE. This report poses the therapeutic challenge of facilitating TRAIL expression in the periphery while inhibiting TRAIL in the CNS.
机译:TNF相关的凋亡诱导配体(TRAIL)在包括实验性自身免疫性脑脊髓炎(EAE)在内的自身免疫性疾病模型中具有良好的抗炎作用。在本期《神经元》中,Aktas,Smorodchenko及其同事提出了证据,证明TRAIL在EAE中发挥抗炎作用,但也诱导神经元凋亡。该报道提出了在外周抑制TRAIL同时抑制CNS中的TRAIL表达的治疗挑战。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号