...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Polarized domains of myelinated axons.
【24h】

Polarized domains of myelinated axons.

机译：髓鞘轴突的极化域。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The entire length of myelinated axons is organized into a series of polarized domains that center around nodes of Ranvier. These domains, which are crucial for normal saltatory conduction, consist of distinct multiprotein complexes of cell adhesion molecules, ion channels, and scaffolding molecules; they also differ in their diameter, organelle content, and rates of axonal transport. Juxtacrine signals from myelinating glia direct their sequential assembly. The composition, mechanisms of assembly, and function of these molecular domains will be reviewed. I also discuss similarities of this domain organization to that of polarized epithelia and present emerging evidence that disorders of domain organization and function contribute to the axonopathies of myelin and other neurologic disorders.
机译：髓鞘轴突的整个长度组织成一系列围绕Ranvier节点的极化域。这些结构域对正常的盐分传导至关重要，由细胞粘附分子，离子通道和支架分子的独特的多蛋白复合物组成。它们的直径，细胞器含量和轴突运输速率也不同。来自有髓神经胶质的近分泌信号指导其顺序装配。将审查这些分子域的组成，组装机制和功能。我还讨论了该结构域结构与极化上皮细胞的相似性，并提出了新兴证据，表明结构域结构和功能障碍会导致髓磷脂和其他神经系统疾病的轴突病变。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号