Are polyglutamine diseases expanding?

Orr HT

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Are polyglutamine diseases expanding?

机译：聚谷氨酰胺疾病正在扩大吗？

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It remains a matter of speculation as to whether the sense CUG-containing RNA and/or the antisense CAG-encoding polyglutamine peptide serves as the pathogenic moiety in Huntington's disease like-2 (HDL2). In this issue of Neuron, Wilburn et al. show that in a HDL2 mouse model, the polyglutamine peptide drives disease progression.

机译：关于包含有义CUG的RNA和/或编码反义CAG的聚谷氨酰胺肽是否充当亨廷顿氏病样2（HDL2）的致病部分，仍是一个猜测问题。在本期《神经元》中，Wilburn等人。表明在HDL2小鼠模型中，聚谷氨酰胺肽可驱动疾病进展。

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《Neuron》 |2011年第3期|共2页
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正文语种 eng
中图分类神经病学;
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1. Conformational changes and aggregation of expanded polyglutamine proteins as therapeutic targets of the polyglutamine diseases: exposed beta-sheet hypothesis. [J] . Nagai Y, Popiel HA Current pharmaceutical design . 2009,第30期

机译：构象变化和扩展的聚谷氨酰胺蛋白的聚集作为聚谷氨酰胺疾病的治疗靶标：暴露的β-表假说。
2. Interference of CREB-dependent transcriptional activation by expanded polyglutamine stretches - augmentation of transcriptional activation as a potential therapeutic strategy for polyglutamine diseases. [J] . Shimohata M, Shimohata T, Igarashi S, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2005,第3期

机译：扩展的聚谷氨酰胺伸展带对CREB依赖性转录激活的干扰-转录激活的增强是聚谷氨酰胺疾病的潜在治疗策略。
3. A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases [J] . Zhang Qian, Chen Zhefan Stephen, An Ying, RNA . 2018,第4期

机译：用于中和膨胀的CAG RNA诱导聚谷氨酰胺疾病中的肽抑制剂
4. Both normal and polyglutamine-expanded ataxin-7 are components of TFTC-type GCN5 histone acetyltransferase-containing complexes [C] . Dominique Helmlinger, Sara Hardy, Adrien Eberlin Biochemical Society Symposium . 2006

机译：正常和聚谷氨酰胺 - 膨胀的阿克突-7是TFTC型GCN5组氨基乙酰转移酶复合物的组分
5. Intranasal Delivery of an Expanded CAG RNA Inhibitor DB213 for Targeting Polyglutamine Diseases [D] . Wang, Qianwen. 2018

机译：扩增的CAG RNA抑制剂DB213的鼻内递送用于靶向聚谷氨酰胺疾病
6. A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases [O] . Qian Zhang, Zhefan Stephen Chen, Ying An, 2018

机译：肽抑制剂可中和多谷氨酰胺疾病中由CAG RNA引起的核仁应激的中和
7. Interference of CREB‐dependent transcriptional activation by expanded polyglutamine stretches – augmentation of transcriptional activation as a potential therapeutic strategy for polyglutamine diseases [O] . M. Shimohata, T. Shimohata, S. Igarashi, 2005

机译：通过膨胀的聚谷氨酰胺延伸，CREB依赖性转录活化的干扰 - 增加转录活化作为聚谷氨酰胺疾病的潜在治疗策略
8. Hunting for huntingtin associated factors: Identification and characterization of huntingtin expanded polyglutamine aggregate associated factors and their impact on Huntington disease model cellular toxicity. [R] . Wear, M. P. 2016

机译：寻找与亨廷顿相关的因素：亨廷顿扩展的聚谷氨酰胺聚集相关因子的鉴定和表征及其对亨廷顿病模型细胞毒性的影响。

Are polyglutamine diseases expanding?

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