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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Rhabdoid glioblastoma: case report and literature review.
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Rhabdoid glioblastoma: case report and literature review.

机译：横纹肌胶质母细胞瘤：病例报告和文献复习。

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摘要

Rhabdoid glioblastoma is a recently described entity in which a glioblastoma is associated with a rhabdoid component. Although rhabdoid glioblastoma has not appeared in the new World Health Organization classification of tumors of the CNS, it has a specific morphological feature and highly aggressive clinic process. Up to now, there have been six cases of rhabdoid glioblastoma reported in the literature. We report rhabdoid glioblastoma in the right front temporal lobe from a 31-year-old Chinese man. This tumor consisted of rhabdoid tumor cells with an eccentric nucleus and an eosinophilic cytoplasm. The tumor had an area appearing to be glioblastoma with microvascular proliferation and necrosis, and lacked a primitive neuroectodermal tumor component, and a mesenchymal component. Vimentin, epithelial membrane antigen, GFAP and integrase interactor (INI-1) expression were found in the tumor cells. Genetic abnormalities which include monosomy or a deletion of chromosome 22 were not found in this tumor. After 3 months post-surgery, the tumor was widespread in leptomeningia and the patient died. In conclusion, rhabdoid glioblastoma is a rare glioblastoma with poor prognosis; the differential diagnosis contained other rhabdoid tumors. This case will contribute to the profile of rhabdoid glioblastoma with typical morphology and immunophenotype, genetic and clinic features.
机译：横纹肌胶质母细胞瘤是最近描述的实体，其中胶质母细胞瘤与横纹肌成分有关。尽管横纹肌胶质母细胞瘤尚未出现在世界卫生组织对中枢神经系统肿瘤的新分类中，但它具有特定的形态学特征和高度侵袭性的临床过程。迄今为止，文献中已有六例横纹肌胶质母细胞瘤病例报道。我们报道了一名31岁中国男子在右前颞叶的横纹肌胶质母细胞瘤。该肿瘤由具有偏心核和嗜酸性细胞质的横纹肌瘤细胞组成。该肿瘤的区域似乎是具有微血管增殖和坏死的胶质母细胞瘤，并且缺少原始的神经外胚层肿瘤成分和间充质成分。在肿瘤细胞中发现波形蛋白，上皮膜抗原，GFAP和整合酶相互作用子（INI-1）表达。在该肿瘤中未发现包括单体性或22号染色体缺失在内的遗传异常。手术后3个月后，该肿瘤广泛存在于软弱症患者中，并死亡。总之，横纹肌胶质母细胞瘤是一种罕见的预后不良的胶质母细胞瘤。鉴别诊断还包含其他横纹肌瘤。该病例将有助于横纹肌胶质母细胞瘤的典型形态和免疫表型，遗传和临床特征。

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