Amyloid + activation = Alzheimer's?

Jagust W

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Amyloid + activation = Alzheimer's?

机译：淀粉样蛋白+激活=老年痴呆症？

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PET imaging of Alzheimer's disease (AD) patients demonstrates Abeta-protein accumulation in a default mode network. In this issue of Neuron, Sperling and colleagues show that cognitively intact individuals with Abeta in this network fail to deactivate it during memory tasks, a finding with important implications for cognitive aging and early detection of AD.

机译：阿尔茨海默氏病（AD）患者的PET成像显示默认模式网络中Abeta蛋白积累。在本期《神经元》中，Sperling及其同事表明，在记忆任务期间，具有该网络的具有认知能力的个体中的Abeta无法使其失活，这一发现对认知衰老和AD的早期发现具有重要意义。

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《Neuron》 |2009年第2期|共3页
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Jagust W;
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正文语种 eng
中图分类神经生理学;
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1. Calpain Activation Promotes BACE1 Expression, Amyloid Precursor Protein Processing, and Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease [J] . Bin Liang, Bao-Yu Duan, Xiu-Ping Zhou, The Journal of biological chemistry . 2010,第36期

机译：Calpain活化促进了阿尔茨海默病转基因小鼠模型中的Bace1表达，淀粉样蛋白前体蛋白质处理和淀粉样蛋白斑块形成
2. Curcumin Attenuates Beta-Amyloid-Induced Neuroinflammation via Activation of Peroxisome Proliferator-Activated Receptor-Gamma Function in a Rat Model of Alzheimer's Disease [J] . Zun-Jing Liu, Zhong-Hao Li, Lei Liu, Frontiers in Pharmacology . 2016,第8期

机译：姜黄素通过阿尔茨海默氏病大鼠模型中过氧化物酶体增殖物激活受体-γ功能的激活来减轻β-淀粉样蛋白诱导的神经炎症。
3. Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer's disease [J] . McDonald Claire L., Hennessy Edel, Rubio-Araiz Ana, Brain, Behavior, and Immunity . 2016,第Null期

机译：抑制TLR2激活衰减阿尔茨海默病小鼠模型中的淀粉样蛋白积累和胶质激活
4. A Cu-Amyloid β Complex Activating Fenton Chemistry in Alzheimer's Disease: Learning with Multiple First-Principles Simulations [C] . Giovanni La Penna, Christelle Hureau, Peter Faller International conference on computational methods in science and engineering 2014 . 2014

机译：在阿尔茨海默氏病中的铜淀粉样β复合物激活Fenton化学：学习与多个第一性原理模拟。
5. Genetic ablation of the platelet activating factor receptor does not impair learning and memory in wild-type mice or alter amyloid plaque number in a transgenic model of Alzheimer's disease [D] . Peshdary, Vian. 2012

机译：血小板活化因子受体的遗传消融不会损害野生型小鼠的学习和记忆，也不会改变阿尔茨海默氏病转基因模型中的淀粉样斑块数
6. Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer’s Disease [O] . Lisa Kirouac, Alexander J. Rajic, David H. Cribbs, 2017

机译：淀粉样前体蛋白和淀粉样β激活Ras-ERK信号和GSK-3促进阿尔茨海默氏病的神经退行性变
7. Calpain Activation Promotes BACE1 Expression, Amyloid Precursor Protein Processing, and Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease* [O] . Liang, Bin, Duan, Bao-Yu, Zhou, Xiu-Ping, 2010

机译：钙蛋白酶激活促进阿尔茨海默氏病转基因小鼠模型中的BACE1表达，淀粉样前体蛋白加工和淀粉样斑块形成*

Amyloid + activation = Alzheimer's?

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