Sensing pH with TMCs

Spalthoff Christian; Goepfert Martin C.

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Sensing pH with TMCs

机译：用TMC感应pH

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Transmembrane channel-like (TMC) proteins have been implicated in hair cell mechanotransduction, Drosophila proprioception, and sodium sensing in the nematode C. elegans. In this issue of Neuron, Wang et al. (2016) report that C. elegans TMC-1 mediates nociceptor responses to high pH, not sodium, allowing the nematode to avoid strongly alkaline environments in which most animals cannot survive.

机译：跨膜通道样（TMC）蛋白已与线虫秀丽隐杆线虫的毛细胞机械转导，果蝇本体感受和钠感测有关。在本期《神经元》中，Wang等人。（2016）报道线虫TMC-1介导了对高pH的伤害感受器响应，而不是对钠的伤害感受器响应，从而使线虫避免了大多数动物无法生存的强碱性环境。

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《Neuron》 |2016年第1期|共3页
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Spalthoff Christian; Goepfert Martin C.;
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正文语种 eng
中图分类神经病学;
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1. Solid state characterization of the anti-HIV drug TMC114: interconversion of amorphous TMC114, TMC114 ethanolate and hydrate. [J] . Van Gyseghem E, Stokbroekx S, de Armas H European journal of pharmaceutical sciences . 2009,第5期

机译：抗HIV药物TMC114的固态表征：无定形TMC114，TMC114乙醇化物和水合物的相互转化。
2. Inhibition of interleukin-3-andinterferon-alpha-induced JAK/STAT signaling by the synthetic alpha-X-2 ',3,4,4 '-tetramethoxychalcones alpha-Br-TMC and alpha-CF3-TMC [J] . Jobst Belinda, Weigl Julia, Michl Carina, Biological chemistry . 2016,第11期

机译：合成的α-X-2'，3、4、4'-四甲氧基查耳酮α-Br-TMC和α-CF3-TMC对白介素3和干扰素α诱导的JAK / STAT信号的抑制
3. Antiviral activity of TMC435 monotherapy in patients infected with HCV genotypes 2-6: TMC435-C202, a phase IIa, open-label study [J] . MorenoC., BergT., TanwandeeT., Journal of Hepatology: The Journal of the European Association for the Study of the Liver . 2012,第6期

机译：TMC435单一疗法对HCV基因型2-6感染的患者的抗病毒活性：TMA435-C202，IIa期，开放标签研究
4. Rapid TMC laser prototyping: Compositional and phase-structural sustainability via combinatorial design of titanium-based gradient alloy reinforced by nano-sized TiC or TiB_2 ceramics [C] . Igor Shishkovsky, Nina Kakovkina, Vladimir Scherbakov Conference on Laser 3D Manufacturing . 2018

机译：快速TMC激光原型制作：通过纳米TiC或TiB_2陶瓷增强的钛基梯度合金的组合设计，成分和相结构的可持续性
5. The roles of structural variability and amphiphilicity of TMC278/rilpivirine in mechanisms of HIV drug resistance avoidance and enhanced oral bioavailability . [D] . Frenkel, Yulia. 2009

机译：TMC278 / rilpivirine的结构变异性和两亲性在避免HIV耐药性和增强口服生物利用度中的作用。
6. Lack of evidence supporting a role of TMC4-rs641738 missense variant—MBOAT7- intergenic downstream variant—in the Susceptibility to Nonalcoholic Fatty Liver Disease [O] . Silvia Sookoian, Diego Flichman, Martin E. Garaycoechea, -1

机译：缺乏支持TMC4-rs641738错义变体MBOAT7基因间下游变体在非酒精性脂肪肝易感性中的作用的证据
7. Metal-Oxo Photo-oxidants, Photochemistry and Photophysics of trans-Os^(VI)(tmc)(O)_2^(2+)(tmc = 1,4,8,11-tetramethyl-1,4,8,11-tetra-azacyclotetradecane) and trans-Os^(VI)(CN)_4(O)_2^(2-) [O] . Che Chi-Ming, Yam Vivian Wing-Wah, Cho Kar-Cheong, 1987

机译：反式-Os ^（VI）（tmc）（O）_2 ^（2 +）（tmc = 1,4,8,11-四甲基-1,4,8）的金属氧光氧化剂，光化学和光物理，11-四氮杂环十四烷）和反式Os ^（VI）（CN）_4（O）_2 ^（2-）
8. Matrix Fatigue Cracking Mechanisms of alpha(2) TMC for Hypersonic Applications [R] . Gabb, T. P., Gayda, J. 1994

机译：高超声速应用α（2）TmC的基体疲劳裂纹机理

Sensing pH with TMCs

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